【作者】 王强；

【导师】 任会鹏；

【作者基本信息】 河北医科大学 ， 精神病与精神卫生学（专业学位）， 2021， 硕士

【摘要】 目的:对精神分裂症及其一级亲属进行事件相关电位N2测验,以探究精神分裂症及其无症状的一级亲属的事件相关电位N2和认知功能的特征,并探究认知功能与事件相关电位N2的关联性。方法:采用听觉oddball范式,对22例精神分裂症患者、24例无症状的精神分裂症一级亲属、27例健康对照组进行事件相关电位N2测试,并分别记录三组受试者N2振幅和潜伏期;对三组受试者分别进行神经认知功能测评,并对事件相关电位N2、神经认知功能之间进行Pearson’s相关分析。结果:1.患者组的N2潜伏期较亲属组和对照组均有延长(均P<0.05),亲属组的N2潜伏期与对照组间差异无统计学意义(P>0.05),三组间的N2振幅差异无统计学意义(均P>0.05);2.患者组在连线测验A、符号编码、霍普金斯词语学习测验、简易视觉空间记忆测验、色词测验、持续性操作测验较亲属组和对照组均有统计学差异(均P<0.05);而亲属组与对照组间在各项认知功能均无统计学差异(均P>0.05)。3.N2潜伏期与连线测试A呈显著的正相关(P<0.05),N2潜伏期与符号编码呈显著的负相关(P<0.05);N2潜伏期与其它认知测验无显著相关性(均P>0.05);N2振幅与各项认知测验均无显著相关性(均P>0.05)。结论:1.事件相关电位N2潜伏期延长可能是精神分裂症的一个神经电生理指标,但不能作为精神分裂症遗传性电生理指标。2.精神分裂症患者存在认知功能损害,而一级亲属认知功能损害不明显。3.事件相关电位N2潜伏期可能和注意力、信息处理速度相关。更多还原

【Abstract】 Objective:In order to explore the characteristics of event-related potential N2 and cognitive function in schizophrenia and its symptomatic first-degree relatives,event-related potential N2 was tested in schizophrenia and its first-degree relatives,and the correlation between cognitive function and event-related potential N2 was explored.Methods:The auditory oddball paradigm was used to perform an auditory N2 test on 22 schizophrenias、24 unaffected first-degree relatives of schizophrenia and 27 healthy controls,and the N2 amplitude and latency were recorded for three groups.At the same time,three groups of subjects were evaluated for neurocognitive function,and Pearson’s correlation analysis was performed among N2 and neurocognitive function.Results:1.The N2 latency of the patient group was longer than that of the relative group(P<0.05)and the normal group(P<0.05).The N2latency of the relative group was not significantly different from that of the control group(P>0.05),and the N2 amplitude of the three groups was not significantly different(P>0.05).2.There were significantly different in Trail Making Test-A,Symbol Coding,Hopkins Verbal Learning Test-Revised,Brief Visual Spatial Memory Test-Revised,Stroop Color word test and Continuous Performance Test in patient group compared with relative group and normal group(P<0.05).3.N2 latency was significantly positively correlated with connection test A(P<0.05),and N2 latency was significantly negatively correlated with symbol coding(P<0.05).N2 latency had no significant correlation with other cognitive tests(P<0.05).The N2 amplitude had no significant correlation with each cognitive test(P>0.05).Conclusions:1.The prolonged latency of event-related potential N2 may be a neuroelectrophysiological indicator of schizophrenia,but it cannot be used as a genetic electrophysiological indicator of schizophrenia..2.Cognitive impairment exists in patients with schizophrenia,but not significantly in first-degree relatives.3.The incubation period of event-related potential N2 may be related to attention and information processing speed.更多还原