【作者】 李丹；

【导师】 黄文；

【作者基本信息】 重庆医科大学 ， 临床医学（专业学位）， 2020， 硕士

【摘要】 目的比较三款治疗髂静脉疾病的血管支架(Wallstent、Smart control及Venovo)的物理性能,为腔内治疗髂静脉压迫和狭窄类疾病支架的选择提供指导依据。方法应用自制支架加压装置测量三款血管支架的抗压力及弯折应力,在数字显影造影(Digital subtraction angiograph,DSA)-3D成形下观测三款支架在受压及弯折时的形变情况,用Imaje软件进行形变面积及形变截面长径和短径的测量并比较。结果在支架抗压力方面,Venovo抗压能力较好,Smart control次之,Wallstent略弱,差异有统计学意义(P<0.017);在柔顺性方面,Venovo较好,Smart control其次,Wallsent柔顺性略差;在弯折形变方面,当弯折至150°、120°时,Wallstent与Smart control比较,差异无统计学意义(P>0.017),弯折至90°时,Smart control形变度明显增大,而Venovo在抗压性、柔顺性及弯折形变度方面均优于其他两款支架,差异有统计学意义(P<0.017)。结论不同的血管支架在力学性能上有很大差异,在选择支架治疗髂静脉压迫、狭窄这类疾病时应参考支架的不同力学特点,在弯曲角度不大时,Smart control和Wallstent弯折形变相近,均可使用,但抗压性能则Smart control抗压能力更佳,且柔顺性更好;而Venovo支架抗压性和柔顺性都较好,在静脉严重狭窄和静脉弯曲度大时均可使用。更多还原

【Abstract】 ObjectiveTo simulate To analyze and compare the physical propertise of three clinical stents(Wallstent,Smart control and Venovo)for the treatment of iliac vein diseases,It provides guidance for the selection of stent for the treatment of iliac vein compression and stenosis in clinic.MethodsThe pressure resistance and bending stress of the three stents(Wallstent,Smart control and Venovo)were measured using a homemade pressurization system.Measuring three stents(Wallstent,Smart control and Venovo)resistance and bending stress,in the digital imaging angiography(DSA)-3D shape under the observation of three stents in the compression and bending deformation,deformation area and deformation by imaje software section long diameter and short diameter measurement,and the relevant data were processed with SPSS 22.,two groups of measuring data with independent sample t-test,three groups and more than three sets of measurement data using analysis of variance.ResultsIn terms of stents’ pressure resistance,Venovo had better resistance to pressure,followed by Smart control,and Wallstent was weaker,with a statistically significant difference(P<0.017).In flexibility Venovo was better,followed by Smart control,and Wallsent was weaker.In the aspect bending deformation,there was no statistically significant difference between the Wallstent and the Smart control when bending to 150° and120°(P>0.017),and the Smart control deformation significantly increased when bending to 90°.However,Venovo was better than the other two stents in terms of compressive resistance,flexibility and bending deformation.ConclusionThere are great differences in mechanical properties of different vascular stents.we are choosing stent in treatment of iliac vein compression and stenosis,we should refer to different mechanics characteristics of these different stents,the bending Angle is small,Smart control and Wallstent have similar bending deformation and can be used,but the compressive performance of Smart control compressive ability and its flexibility is better;However,the Venovo stent has good compression resistance and flexibility,and can be used in severe venous stenosis and large venous curvature.更多还原