【作者】 李思；

【导师】 张国强；

【作者基本信息】 河北医科大学 ， 皮肤病与性病学（专业学位）， 2018， 硕士

【摘要】 银屑病是一种慢性、复发性、炎症性皮肤病,其发病机制复杂,确切机制尚不清楚,目前认为是遗传因素与环境因素等相互作用而导致的多基因遗传病,有家族遗传倾向。表观遗传学是当前国内外研究的热点之一,是一门DNA序列不发生变化,基因表达发生可遗传改变的学科,主要机制包括DNA甲基化、组蛋白修饰及非编码RNA调控,肿瘤及多种自身免疫性疾病的发生发展过程有表观遗传学改变。近年来许多证据表明银屑病的发病与表观遗传学有一定相关性,银屑病目前尚没有治愈方法,对其表观遗传学的研究或许可以为银屑病的治疗提供新的思路和前景。本文就银屑病在表观遗传学研究中DNA甲基化、组蛋白修饰以及非编码RNA调控的进展作一综述。更多还原

【Abstract】 Psoriasis is a chronic,recurrent and inflammatory skin disease,its pathogenesis is complex,and the exact mechanism is not clear,is currently considered to be genetic and environmental factors and other interactions caused by polygenic disease,familial genetic predisposition.Epigenetics is one of the hotspots in the field both at home and abroad.It is a subject whose DNA sequence does not change and whose gene expression can be genetically altered.Its main mechanisms include DNA methylation,histone modification and non-coding RNA regulation,there are epigenetic changes in the development of tumors and various autoimmune diseases.In recent years,there is a lot of evidence that the incidence of psoriasis and epigenetics have some relevance.Psoriasis is currently no cure,and its epigenetic studies may provide new ideas and prospects for the treatment of psoriasis.This article reviews the progress of DNA methylation,histone modification and non-coding RNA regulation of psoriasis in epigenetic studies.更多还原