【作者】 张静；

【导师】 吴海明； 杜俊宝；

【作者基本信息】 河北北方学院 ， 中西医结合临床（专业学位）， 2018， 硕士

【摘要】 本试验通过观察痤疮消融膏治疗痰瘀结聚型结节囊肿性痤疮的临床疗效,探讨痤疮消融膏的使用价值,为临床开发一种确实有效的纯中药成分的外用乳膏。试验中选取2016.12-2017.08在石家庄市中医院皮肤科门诊就诊的80例符合纳入标准的痰瘀结聚型囊肿性痤疮的患者采用计算机产生随机数的方法分为两组:试验组每天早晚共两次均采用痤疮消融膏涂擦于患部;对照组每天早晨采用克林霉素磷酸酯凝胶一次和每天晚上采用他扎罗汀乳膏一次涂擦于患部。比较两组的粉刺、丘疹、脓疱、结节、囊肿的类型及数目,皮损质地,皮损疼痛,皮损颜色,皮损大小,皮损部位,皮损油腻程度的差异,从而计算出试验组和对照组的综合疗效。综合疗效的评定是根据治疗前后皮损的改善情况计算出有效率,再参照尼莫地平法将有效率分为临床痊愈、显效、有效和无效四个等级,从而做出痤疮消融膏的临床疗效的评价。在本院收集符合标准的痰瘀结聚型结节囊肿性痤疮患者共80例。其中男性患者47例,女性患者33例;年龄均在18~35岁之间,平均年龄为24.06岁;病程均在2月-5年之间,平均病程为1.5年;治疗前试验组皮损平均积分25.80分,对照组平均积分为24.68分;在试验过程中无脱落及剔除病例;两组在年龄、性别、病程长短、病情轻重方面经统计学研究,P>0.05,没有显著差异,具有临床可比性;两组受试者在治疗前总积分经非参数(M-W)检验显示,Z=-0.621,P=0.535(P>0.05),表明无显著差异,具有临床可比性;两组受试者在治疗前皮损类型评分值经非参数(M-W)检验显示,各组P>0.05,表明两组受试者治疗前在皮损类型上无显著差异,具有临床可比性;两组受试者在治疗后皮损类型评分值经非参数(M-W)检验显示,除部位积分外,其余各组P<0.05,表明两组受试者治疗后皮损有显著差异;对照组在治疗前后皮损类型评分值样本经wilcoxon秩和检验显示,各组P<0.05,说明对照组治疗前后皮损有显著差异;试验组在治疗前后皮损类型评分值样本经wilcoxon秩和检验显示,各组P<0.05,说明试验组治疗前后皮损有显著差异;治疗后试验组总有效率为77.50%,对照组总有效率为65.00%,表明试验组综合疗效优于对照组。综上,痤疮消融膏能够降低痰瘀结聚型结节囊肿性痤疮皮疹症状积分,改善皮损症状,对痰瘀结聚型结节囊肿性痤疮有治疗作用。更多还原

【Abstract】 Background and significance: acne,also known as "acne," "acne," "acne," is a good hair in adolescence,clinical common sebaceous gland tube and pores due to congestion,so that sebum flow in the skin is not free of chronic inflammatory skin.Acne is most common in the face,and some of it occurs in the chest and back.In addition,acne has a variety of manifestations,such as pincers,papules,cysts,pustules,nodules,and so on.Nodular cystic acne is the third,fourth,and also belongs to the more severe classification,mainly skin lesions formed cysts or nodules,more than 3,and more with pain.Because it has damage tolerance,it brings some psychological pressure to patients.Although there are many kinds of methods in the treatment of acne in Western medicine,there is a lack of pertinence to the treatment of sarcocystic acne,and some drugs have certain limitations.Therefore,it is urgent to seek a safe,effective,widely applicable and highly targeted topical drug.In view of the above,Professor Lilinge,through the analysis of the domestic and foreign literature and the investigation and follow-up of the clinic of sarcocystic acne,combined with many years of clinical experience,made a self-made needle for sarcocystic acne,a pure Chinese medicine ingredient of the external acne cream,for patients with sarcocystic acne brought good news,but also for medical treatment of sarcocystic acne development of a pure Chinese medicine ingredient external preparation.Objective: To observe the clinical curative effect of acne-aluminate in treating acne-nodular cystic acne with phlegm stasis,to explore the value of acne-aluminate,and to develop an effective external cream with pure traditional Chinese medicine.Methods: 80 cases of phlegm stasis cysticercoid acne patients who attended dermatological clinic in Shijiazhuang Hospital were divided into two groups.Two times a day,morning and evening,the experimental group were coated with acne ablation ointment;The control group was given clindamycin phosphate gel every morning and taradin cream every night.The types and numbers of acne,papules,pustules,nodules and cysts,the texture of skin lesions,skin lesions,color of skin lesions,size of skin lesions,skin lesions and the degree of greasy skin lesions in the two groups were compared.The comprehensive evaluation of curative effect was effective in the calculation of skin lesions.According to nimodipine method,it was divided into four levels: clinical recovery,clinical efficacy,efficacy and invalidity.The results were as follows: 28 days after the treatment,the scores of acne,papules,pustules,nodules,cysts,skin lesions were better than those of the control group.Conclusion: Acne ablation cream is superior to Kelin and Taloxone cream in the treatment of nodular cystic acne.更多还原