【作者】 王欢；

【导师】 夏先平；

【作者基本信息】 华中科技大学 ， 材料学， 2016， 硕士

【摘要】 本文以聚氧化乙烯(PEO)与低密度聚乙烯(LDPE)的聚合物合金为基体、采用粉料共混/注塑成型技术构建了一种用于制备新型宫内节育器的聚合物合金基含铜复合材料,即铜/聚氧化乙烯/低密度聚乙烯(Cu/PEO/LDPE)复合材料,并对该复合材料的成型工艺、组织结构、力学性能、亲水性以及铜离子释放性能进行了研究。对Cu/PEO/LDPE复合材料成型工艺的研究表明,该复合材料合适的注塑成型工艺为:注塑压力60bar、注射温度165℃、加热温度180℃、保压压力10bar、保压时间0.5s、注塑速率70%。对Cu/PEO/LDPE复合材料组织结构的研究表明,该复合材料是纯Cu、纯PEO和纯LDPE的简单混合物;其中PEO的添加使得复合材料基体LDPE的结晶度降低,同时当Cu/PEO/LDPE复合材料浸泡到模拟宫腔液后,由于其中PEO的溶解,使得复合材料呈现出一种纳米尺度且连通性较好的多孔结构。对Cu/PEO/LDPE复合材料性能的研究表明,该复合材料的各种性能均可以通过改变PEO含量或/和Cu含量来调控。其力学性能随PEO含量或Cu含量的增加而降低,但其亲水性及铜离子释放速率均随PEO含量或Cu含量的增加而提高,且PEO含量对各种性能的影响比Cu含量更加显著。特别是,在力学性能均不劣于现有含铜宫内节育器支架材料的前提下,与Cu含量同为15 wt.%的Cu/LDPE复合材料相比,当Cu/PEO/LDPE复合材料中PEO含量为8 wt.%时,其在模拟宫腔液中的接触角比Cu/LDPE复合材料小35.55°,其在模拟宫腔液中的铜离子释放速率比Cu/LDPE复合材料高20倍左右。这些结果表明,该新型的聚合物合金基含铜复合材料具有比Cu/LDPE复合材料更优异的生物相容性,同时在铜离子释放速率相同的情况下可使所制备宫内节育器的重量减轻4.5倍左右,它将是一种更加优异的含铜节育器材料。更多还原

【Abstract】 In this paper, a novel copper-containing composite based on PEO-LDPE polymer alloy for intrauterine devices(IUD), i.e., copper/polyethylene oxide/low-density polyethylene(Cu/PEO/LDPE) composite, has been proposed and developed successfully by using the powder blending and injection molding technique. Then, its injection molding process, structure, mechanical properties, hydrophilicity and cupric ions release behavior were investigated.Study on the injection molding process of the Cu/PEO/LDPE composite shows that the appropriate injection process parameters of preparing the Cu/PEO/LDPE composite are 60 bar of injection pressure, 165 ℃ of injection temperature, 180 ℃ of barrel temperature, 10 bar of packing pressure, 0.5 s of packing time and 70 % of injection rate.Study on the strcture of the Cu/PEO/LDPE composite shows that the Cu/PEO/LDPE composite is a simple hybrid of the pure Cu, the pure PEO and the pure LDPE. Additionly, the crystallinity degree of its LDPE matrix decreases due to the introduction of PEO. After the Cu/PEO/LDPE composite was immersed in simulated uterine solution, nano-sized and well interconnected porous structure is obtained in its LDPE matrix.Study on the properties of the Cu/PEO/LDPE composite shows that its properties can be easily regulated by changing the PEO content or/and the Cu content. With the increasing of its PEO content or its Cu content, its mechanical properties decrease, but its hydrophilicity and cupric ions release rate increase, and the influence of the PEO content on its properties is more remarkable than that of the Cu content. Especially, under the conditions that its mechanical properties are not inferior to that of the scaffold material of the existing Cu-IUD, the contact angle of the Cu/PEO/LDPE composite with 15 wt.% of Cu and 8 wt.% of PEO is 35.55° smaller than that of the Cu/LDPE composite with the same content of Cu, and its cupric ions release rate is about 20 times higher than that of this Cu/LDPE composite. These results indicate that this Cu/PEO/LDPE composite has a much better biocompatibility than that of the Cu/LDPE composite, and the weight of Cu-IUD prepared with this Cu/PEO/LDPE composite would be about 4.5 times smaller than that prepared with this Cu/LDPE composite when they have the same cupric ions release rates, indicating that the Cu/PEO/LDPE composite would be a more excellent material for Cu-IUD.更多还原