【作者】 吴平；

【导师】 李平华；

【作者基本信息】 重庆医科大学 ， 眼科学， 2016， 硕士

【摘要】 目的:评估康柏西普在新生血管性青光眼(NVG,neovascular glaucoma)综合治疗中的临床疗效。方法:回顾分析NVG患者共55例66眼并将其分为两组,其中A组共25例31眼行康柏西普玻璃体腔注射治疗+传统方式治疗即全视网膜光凝术(PRP,Panretinal photocoagulation)和青光眼滤过性手术,B组共30例35眼接受单纯传统方式治疗,将NVG患者按照患眼的严重程度分为三期,对比分析不同临床分期患眼在两种疗法治疗前和治疗后3d、1w、1m、3m及末次随访的临床效果。评估要素为治疗前后的最佳矫正视力(BCVA,best corrected visual acuity)、眼压、虹膜新生血管(INV,Iris neovascularization)、治疗并发症等。结果:A组较B组在NVG一期、二期对于视力的提高更为显著且差别存在统计学意义(P<0.05),在NVG三期两组患眼治疗后视力的差别无统计学意义(P>0.05)。A组较B组对NVG二期与NVG三期患眼在治疗后1w、1m、3m时降低眼压的效果更明显(P<0.05),但在末次随访时A组与B组的眼压无明显差异(P>0.05)。A组较B组在治疗后1m、3m、末次随访时消褪INV的效果更为显著(P<0.05)。结论:康柏西普联合传统治疗方法可以安全有效提高NVG患眼视力、降低眼压、消退虹膜新生血管,而且效果优于单纯传统治疗方法。更多还原

【Abstract】 Objective: To evaluate the clinical effects of intravitreal injection of Conbercept in the treatment of neovascular glaucoma.Methods: A total number of 55 patients with 66 eyes of NVG were retrospective analyzed and divided into two groups, A group including 25 patients with 31 eyes accepted intravitreal injection of Conbercept combined traditional treatments, while B group including the other 30 patients with 35 eyes only accepted the traditional treatments including PRP(Panretinal photocoagulation, PRP) and glaucoma filtering operation. The sick eyes were divided into different clinical stages according to the severity. The clinical effects of two different therapies in the treatment of different stages of NVG were analyzed by comparing the evaluation factors of before and after the treatment of 1 day, 7 days, 1 month, 3 months and the final follow-up, and the evaluation factors including BCVA(Best corrected visual acuity, BCVA), IOP( intraocular pressure, IOP), INV(iris neovascularization,INV) and treatment of complications etc.Results: Patients with NVG stage 1 and 2 in A group had more significant improvement of BCVA as compared with patients in B group(p<0.05),while there is no significant difference between the two groups of patients with NVG stage 3(p>0.05). Patients with NVG stage 2 and 3 in A group had more significant decrease of IOP after the treatment of 1week, 1 month and 3 month as compared with patients in B group(p<0.05),however there is no significant difference between the two groups in IOP in the final follow-up(p>0.05). When compared with B group, patients in A group had more significant effects in the extinction of INV after the treatment of 1 month, 3 month and the final follow-up.Conclusion: Conbercept combined traditional treatment is safe, effective and better than simple traditional treatment for patients with neovascular glaucoma in the improvement of BCVA, decrease of IOP, extinction of INV.更多还原