【作者】 黄红娟；

【导师】 魏跃钢；

【作者基本信息】 南京中医药大学 ， 皮肤性病学， 2007， 硕士

【摘要】 背景：雄激素源性脱发，中医称之为“发蛀脱发”，又称“蛀发癣”，西医又名男性型秃发、雄激素源性脱发。该病是皮肤科临床的常见病、多发病，也是难治疾病之一。现代医学多认为本病的发生与性激素平衡失调、皮脂腺分泌过多有关。现代医学己证明雄激素性脱发是由雄激素依赖的多基因遗传性皮肤病，并与遗传、内分泌、免疫、精神等方面关系密切。而大多数雄激素源性脱发患者都伴有头皮油脂分泌过多。本研究通过对雄激素源性脱发患者头皮油脂分泌的测定，进一步探讨中药汤剂对雄激素源性脱发患者头皮油脂分泌的影响。目的：复方茵陈方对雄激素源性脱发患者头皮油脂分泌的影响；脾胃湿热即表现为皮脂分泌异常是否与本病的发生存在相关性，提示湿热为本病的病机之一，从而为清热利湿法治疗本病提供依据。方法：雄激素源性脱发脾胃湿热型的患者，共61例，治疗组41例，对照组20例。用皮肤油脂水分酸碱度测试仪在其前额、顶部、后枕部测得三个油脂分泌数值，并进行统计学分析。结果：1、治疗组及对照组前额部治疗前后无明显变化。2、后枕部为健发区，两组测得结果治疗前后亦无明显差异。3、治疗组及对照组顶部治疗前明显高于前额及后枕部，治疗前后有明显差异，且治疗组优于对照组。4、顶部油脂指数偏高可能与头顶部皮脂腺分布过多有关。结果表明复方茵陈方对降低雄激素源性脱发患者顶部油脂分泌方面明显优于西药组。讨论：1、复方茵陈方可以从机体调节，从而降低头顶部皮脂腺的分泌，改善临床症状。2、脾胃湿热即表现为皮脂分泌异常可能与本病的发生存在相关性，提示湿热可能为本病的病机之一。更多还原

【Abstract】 Background: Alopecia alopecia was called male pattern alopecia orandrogenetic seborrheica in western medicine.It is a common and frequently occurringillness in dermatology and hard to be cured. Modern medicine usually considers that it isrelated to sexual hormone disequilibrium and sebaceous gland hypersecretion.Modern medical science has already proved the androgen alopecia is the many genesheredity skin disease relied on by the androgen, and such respects as the heredity,endocrine, immunity, spirit, etc. are in close relations.Most of the patients have thesymptom of over sebum secretion.Objective: 1,The influence of the compound prescription YINCHEN soup on the sebum ofthe scalp of the androgenetic alopecia patient;2,To study the relations between the abnormality of scalp sebum secretion andthe onset of androgenetic alopecia; to hint that SHIRE is one of the pathogenesis.Method: the androgenetic alopecia Dampness-Heat in the Spleen and Stomachpatient,altogether 61 examples,treatment group 41 examples,comparison group20examples.Obtain three data from the forehead,the top of the head and the occiput of eachpatient with the combination device(sebumeter SM810/corneometer CM825/skin-pH-meterPH900), and carries on statistics analysis.Result: 1,there is no obvious changment on the forehead sebum before and after thetreatment in both treatment group and comparison group.2,the data of the occiput from two groups isnot obvious different.3,the data of the crown has changed greatly after the treatment in both groups.Andthe result is that the treatment group is superior to the comparison group.4,the high level of the sebum of the scalp may be ralated to the spread of the sebum.the result indicates that the compound prescription YINCHEN soup reduces sebumof the scalp is better than western medicine group.Conclusion: 1, the compound prescription YINCHEN soup can reduces the sebum of thecrown by organism adjustment, then improves clinical symptom.2,the abnormality of scalp sebum secretion may be related to the onset ofandrogenetic alopecia; and SHIRE may be one of the pathogenesis.更多还原