【作者】 刘琦；

【导师】 李占双；

【作者基本信息】 哈尔滨工程大学 ， 应用化学， 2009， 硕士

【摘要】 水滑石独特的层间阴离子可交换性,使其在插层水滑石方面得到很大的发展。在LDHs材料中插入药物分子,将其作为药物活性分子的传输载体已成为LDHs研究领域的新焦点,这些材料在运输、储存、可控释放药物分子方面具有很大的潜力。本文对水滑石材料进行功能化,制备出一种兼有发光性能和磁靶向功能的新型药物载体。利用水滑石的“记忆效应”,分别以碳酸根型水滑石和氢氧根型水滑石为前驱体,在室温下采用焙烧复原法将药物分子阿莫西林以阴离子的形式嵌入到磁性锌铝水滑石层间,得到具有磁靶向定位功能的药物插层水滑石。XRD研究表明(003)晶面衍射峰对应的20向小角度偏移,AMX阴离子在层间主要以单层形式排布,并与垂直于层板的(003)晶面方向成37°角倾斜；磁性研究表明该样品具有顺磁性,在外加磁场的作用下,可实现靶向定位功能。利用LDHs层板阳离子的可替代性,采用水热法合成了层板掺稀土Eu3+的磁性镁铝铕水滑石,通过离子交换法,将药物模型分子对氨基苯磺酸以阴离子的形式插层进入层间,得到具有荧光发光性能和靶向定位功能的药物插层水滑石。XRD研究表明(003)晶面衍射峰对应的20在5.5°,对氨基苯磺酸阴离子以齿状交错单层的形式在层间排布；荧光发射光谱中出现Eu3+的最低激发态5D0的四种特征跃迁,分别为5D0→7F1、5D0→7F2、5D0→7F3和5D0→7F4,表现出发光性能,可以用于对药物的跟踪检测;同时该样品也具有顺磁性。用pH=7.4的磷酸盐缓冲溶液模拟人体内环境的药物释放实验发现,水滑石型载药体系均具有缓释性能,且释放过程相似,释放初期为快速释放,随后为一个缓慢释放的过程；药物释放动力学表明,整个缓释曲线较好地符合Peppas方程,释放过程主要包括LDHs层板的溶解,药物阴离子在层间扩散过程以及药物阴离子与磷酸盐缓冲溶液中阴离子的离子交换过程。更多还原

【Abstract】 LDHs’peculiar interlayer anionic exchange capacity makes it have a great development in intercalated hydrotalcite fields. Many drug molecules have been intercalated into the LDH interlayer, LDHs as active drug delivery carriers have been a new focus in LDHs research fields, thus these materials have a great potential in the transport, storage, and controlled release of drug molecules. In this paper, a novel drug carriers with luminescent and magnetic characteristics will be synthesized through functionalizing the hydrotalcite-like materials.On the basis of the structural "memory effect" of layered double hydroxides, amoxicillin anions were intercalated into the interlayer space of magnetic zinc-aluminum-LDHs by calcinations-reconstruction method using carbonate pillared LDHs and hydroxyl pillared LDHs as precursors respectively. XRD pattern of the obtained sample showed that 2θangle corresponding to (003) basal reflection moved to lower angle at about 7°, thus it was suggested that the interlayer AMX anions were arranged as a monolayer and tilted at an angle of 37°with respect to crystal plane (003) direction. Furthermore, magnetic analysis results indicated that the obtained sample exhibited paramagnetic characteristics, thus it can realize targeted localization function by an external magnetic field.Using the isomorphous substitution of cation in LDHs layers, magnetic magnesium-aluminum-LDHs which contain rare earth Eu3+in layers were synthesized by hydrothermal method, then sulfanilic acid anions were intercalated into the interlayer space of magnetic zinc-aluminum-europium-LDHs by ion exchange method. XRD results showed that 2θangle corresponding to (003) basal reflection moved to 5.5°, it can be predicted that sulfanilic acid anions existed as a monovalent and adopted dentate staggered oriented parallel arrangement. Four characteristic transitions lines from the excited 5D0 level of Eu3+ can be observed in the emission spectra,5D0→7F1,5D0→7F2,5D0→7F3 and 5D0→7F4, respectively. These features showed that zinc-aluminum-europium-LDHs possessed luminescence properties which can be used to track and monitor drug. Furthermore, the samples also exhibited paramagnetic characteristics.In vitro drug release experiments in pH 7.4 phosphate buffer solution of simulated body intestinal condition showed that all the samples displayed the sustained release properties. All the samples have a similar release process, with a fast release at initial stage followed by a relatively slower release. The research on drug release kinetics demonstrated that the whole release curves of all the samples were best fitted with Peppas models. The release process included the diffusion of drug anions in the LDHs interlayers, the ion exchange process that drug anions were exchanged by anions in phosphate buffer solution and the dissolution of LDHs hydroxide sheets.更多还原