【作者】 刘莹；

【导师】 马晓欣；

【作者基本信息】 中国医科大学 ， 妇产科， 2010， 硕士

【摘要】 目的研究WT1在子宫内膜病变中的表达规律及其在子宫内膜癌的发生、预后评估的临床价值。方法用免疫组化法(S-P)检测增生期、分泌期正常子宫内膜各5例做为对照组,子宫内膜单纯性增生10例、非典型增生33例、子宫内膜癌40例,共83例做为实验组,观察WT1在正常子宫内膜及不同子宫内膜病变中的阳性表达。结果1、WT1在内膜单纯性增生、非典型增生中阳性表达与对照组比较无统计学差异(P＞0.05)。2、WT1在子宫内膜腺癌中的表达明显升高,与对照组比较有统计学意义(P＜0.01)。WT1阳性表达率与子宫内膜癌的手术-病理分期(P＜0.05)、组织分化程度(P＜0.05)、淋巴转移(P＜0.05)有关。结论WT1与子宫内膜癌的发生、发展密切相关,WT1表达增加提示子宫内膜病变恶性程度高,且预后不良。更多还原

【Abstract】 ObjectiveTo investigate the expression of WT1 in Endometrial Diseases and its clinical significance for the incidence of endometrial carcinoma and evaluation for prognosis.MethodControl group:10 cases including 5 of proliferative endometrium and 5 of secretory endometrium.Experimental group:83 cases including 10 of endometrial hyperlpasia,33 of atypical proliferation,40 of endometrial carcinoma.Detect the expression of WT1 in these cases with immunohistochemistry.Results1、Expression of WT1 in endometrial hyperplasia atypical proliferation have no statistical significance between the control group and experimental group (P＞0.05).The expression of WT1 obviously increase in endometrial carcinoma and there is significance (P＜0.01) compared with control group.2、The positive rate of WT1 is correlation with the clinical phase (P＜0.05), grade of cellular differentiation (P＜0.05) and lymphonode metastasis (P＜0.05).ConclusionsWT1 is related to the incidence and development of endometrial carcinoma.The over expression WT1 indicates a poor prognosis of patients with endometrial carcinoma.更多还原