【作者】 张辉；

【导师】 唐中华；

【作者基本信息】 中南大学 ， 普通外科学， 2009， 硕士

【摘要】 目的:探讨溶骨性骨代谢标志物血Ⅰ型胶原交联羧基末端肽(ICTP)和血抗酒石酸酸性磷酸酶5b(Tracp 5b)定量检测诊断乳腺癌骨转移的价值。方法:用ELISA方法测定78例乳腺癌患者及40例乳腺良性肿瘤患者血清ICTP和Tracp 5b水平。结果:乳腺癌骨转移组患者血ICTP浓度和血Tracp 5b均明显高于无骨转移组合对照组(p＜0.001),无骨转移组与对照组间无显著差异。乳腺癌患者血清ICTP和Tracp 5b浓度表达成正相关(r=0.63,p＜0.01)。血ICTP诊断乳腺癌骨转移的敏感性、特异性和准确性分别为55.3%、92.5%、81.4%;血Tracp 5b诊断乳腺癌骨转移的敏感性、特异性和准确性分别为84.2%、83.8%、83.9%。两者联合诊断乳腺癌骨转移的敏感性、特异性和准确性分别为94.7%、81.3%、85.6%。结论:血ICTP和血Tracp 5b对乳腺癌骨转移的诊断均有重要价值,两者联合有助于提高乳腺癌骨转移的敏感性和准确性。更多还原

【Abstract】 Objective: To evaluate the benefits of using new bone metabolic markers such as serum pyridinoline crosslinked C-telopeptides of type I collagen (ICTP) and serum tartrate-resistand acid phosphatase(TRACP) 5b in the detection of bone metastasis in patients with breast cancer and 40 patients with fibroadenoma.Methods: The levels of serum ICTP and serum Tracp 5b in 78 patients with breast cancer were measured using ELISA.Results: The level of all bone markers in patients with bone metastasis was significantly higher than in the patients without bone metastasis (p<0.001). Higher serum ICTP and serum Tracp 5b were detected and a significant correlation was seen between the two markers (r=0.63,p<0. 01). The sensitivity, specificity and accuracy of serum ICTP was 55.3%、92.5%、81.4%, and the sensitivity, specificity and accuracy of serum Tracp 5b was 84.2%、83.8%、83.9%, respectively. The sensitivity, specificity and accuracy of the combined application of serum ICTP and Tracp 5b was 94.7%、81.3%、85.6%.Conclusion: Serum ICTP and blood Tracp 5b have important value to the diagnosis of bone metastasis wih breast cancer . The combined application of serum ICTP and Tracp 5b is contributed to improve the diagnostic sensitivity and accuracy of bone metastasis with breast cancer.更多还原