【作者】 钟鸣；

【导师】 钱志余；

【作者基本信息】 南京航空航天大学 ， 精密仪器及机械， 2008， 硕士

【摘要】 光学相干层析成像术(OCT)是一种无损伤、非侵入、高分辨率及实时在位生物组织微观医学成像技术,是当前成像技术的研究热点之一。本文基于OCT系统的成像基础理论,结合国内外OCT系统的研究现状,以提高OCT系统的性能价格比为目标,以降低光源成本和提高系统纵向分辩率为出发点,在系统的设计原理、调试、数据处理等方面进行了初步的探讨,主要研究内容包括:1、根据OCT系统的基本原理,分析了传统OCT系统的优缺点,提出了一种改进的系统设计方案。改进后的系统具有更高的性价比,大大降低了光源成本,便于推广应用。2、设计了一套基于光纤传播的OCT系统,该系统选用中心波长为1310nm,半高谱宽为32nm的双SLD作为光源,其中最高模式半高谱宽为50nm。采用这种光源的系统具有30μm左右的横向分辨率和8~25μm的纵向分辨率。3、运用NI公司的LabVIEW软件作为开发平台,编写了数据采集与处理程序,获取了较高质量的一维图像信息。与国内外同类系统实验结果相比,采用改进后的系统能够实现生物组织的高分辨率成像,同时也表明了系统具有较高探测灵敏度、无损伤、非侵入性等特点,其较高性价比可以使光学相干层析成像技术在生物组织测量和医学成像研究等方面得以推广应用。更多还原

【Abstract】 The optical coherence tomography(OCT) is one of the novel tomography imaging technique, which possess the capability of non-invasion in vivo imaging the microstructure of biological tissue with high resolution. To improve the properties-to-cost ratio and elevate the axis resolution of the OCT system, we hereby referred the fundamental theory of OCT system coordinating with the trend of modern development of OCT system, and thus, intensively investigated the design, debugging, data process and application of OCT system. The details are described as following:1. According to the basic theory of OCT, the shortcoming and advantages of the conventional system were analyzed, and the new ideas for ameliorating the design of OCT system were brought forward. The ameliorated OCT could not only decline the price of the source greatly, but also have better properties-to-cost ratio than conventional one. It thus has potential spread application.2. An optical-fiber-based OCT system was designed. In this new system, a double SLD sources, with center-wave of 1310nm and up to 50nm Full Width at Half-Maximum Width (FWHM), is chosen. A longitudinal resolution of 8 to 25μm and transverse resolution of 30μm were achieved in the imaging of bio-tissue.3. A high quality one-dimensional imaging was achieved by using the LabVIEW virtual instrument platform (provided by NI), which has the capability of real-time and in vivo data acquisition, storage, processing and displaying result.In comparison to the conventional and other current system, our ameliorated OCT system was proven in the experiment to be able to obtain bio-tissue structure with high resolution and sensitivity. Furthermore, as the performance of the system was optimized with high properties-to-cost ratio, this system would extend its application in experimental study and clinic of bioengineering.更多还原