【作者】 霍会爱；

【导师】 杨质秀；

【作者基本信息】 黑龙江省中医研究院 ， 中医内科学， 2008， 硕士

【摘要】 目的:本课题以中医理论为指导,观察通络化纤颗粒治疗特发性肺间质纤维化(IPF)的临床疗效。方法:纳入60例特发性肺间质纤维化患者,随机分为两组:治疗组30例和对照组30例,治疗组给予通络化纤颗粒和强的松;对照组给予强的松,两组均设3个月为一个疗程,连续观察2个疗程。分别观察两组治疗前后临床症状及体征、肺功能、血气分析、胸部HRCT及观察期间肺部再感染次数及使用抗生素的变化情况。结果:治疗组总有效率为83.33%,优于对照组的60.00%(P<0.05)。临床观察结果显示,两组病例治疗后临床症状、体征积分及总积分均较治疗前明显降低(P<0.01,P<0.05),并且治疗组改善更显著(P<0.05)。治疗组肺总量、肺活量、肺弥散功能较治疗前均有提高(P<0.05),两组病例动脉血氧分压均升高,但治疗组优于对照组(P<0.05),有显著性差异。两组病例治疗前后的胸部HRCT比较,无显著性差异(P>0.05)。治疗组肺部再感染次数及使用抗生素情况明显低于对照组(P<0.05)。结论:通络化纤颗粒不仅能改善特发性肺间质纤维化的临床症状、体征,改善肺功能、提高动脉血氧分压,延缓肺纤维化进程,而且能够减少肺部再感染的机会,减少药物毒副作用,提高患者的生存质量。更多还原

【Abstract】 Objective: This experiment takes Chinese medicine theories as an instruction, to observe the clinical effect of tongluo fiber particles on idiopathic pulmonary fibrosis （IPF） patients.Methods: 60 cases patients with idiopathic pulmonary fibrosis were randomly divided into two groups,the treatment group （30 cases） and the control group （30 cases）. All patients were given drugs for 3 months and were observed two treatment stages.The treatment group was treated with Tongluo fiber particles and Prednisolone. The control group was treated with Prednisolone.The changes of clinical symptoms and signs, the pulmonary function test, blood gas analysis，the HRCT，the occurrence of lung reinfection rate and the make use of antibiotic were observed before and after the treatment.Results: The total effective rate was 83.33% in the treatment group ,better than 60.00% of the control group（P<0.05）. The total symptom and sign scores in two groups all decreased than pre-treatment （P<0.01, P<0.05）, after the treatment group decreased more significantly （P<0.05）. The treatment group with significantly increased the pulmonary function index such as TLC, VC, Dlco compared than pre-treatment（P<0.05）. In both group,PaO2 all decreased than pre-treatment,but the treatment group with significantly increased PaO2 compared to the control group（P<0.05）. The HRCT results showed there was no significant difference between groups（P>0.05）. The occurance of lung reinfection and the make use of antibiotic in the treatment group were lower than the control group within the treatment period and the difference between was significant（P<0.05）.Conclusion: Tongluo fiber particles could not only improve the clinical symptoms and signs, the pulmonary function,increase PaO₂,but also reduce the occurance of lung reinfection rate and the adverse effects. Meanwhile, it could delay the course of pulmonary fibrosis, enhance the existent quality of patients.更多还原