【作者】 董子梅；

【导师】 秦超；

【作者基本信息】 广西医科大学 ， 神经病学， 2008， 硕士

【摘要】 目的:通过分析大脑中动脉M₁段狭窄或闭塞患者的CT灌注成像改变,探讨其在大脑中动脉狭窄患者中的临床应用价值。方法:11例经DSA检查确诊的大脑中动脉M₁段狭窄或闭塞的患者,与7例经DSA检查证实的无局限性狭窄患者作对照。所有患者均行头颅CT灌注成像检查,并对其图象行定量分析。并同时行头颅CT和/或MRI检查。最后与DSA检查、CT和/或MRI检查结果进行对比分析。结果:1、11例患者的灌注图与对照组比较均出现了不同程度的灌注改变。2、MCA狭窄患者MCA供血区CBF、CBV的患健比值与对照组比值相比较,无显著性差异（P＞0.05）,而TTP的患健比值与对照组比值相比较,有显著性差异（P＜0.05）。3、（1）将11例患者的灌注改变按脑梗死前期的CT灌注分型,Ⅰa期患者5例,Ⅰb期患者3例,Ⅱa期患者1例,Ⅱb期患者2例。（2）11例患者其动脉狭窄率与脑梗死前期的分型无相关性。结论:CT灌注成像是一种评价动脉狭窄后局部血流动力学改变的敏感方法;TTP是最敏感的指标之一。更多还原

【Abstract】 Objective to analysis the change of CT perfusion imaging in patients with the stenosis in the part of M₁ stage of middle cerebral artery, to evaluate the value of CT perfusion imaging in clinical application.Methods After the the examination of Digital substraction angiography （DSA）, 11 patients with the stenosis in the part of M₁ stage of middle cerebral artery and 7 patients with no any local stenosis had been collected in our research as control group. CT perfusion imaging and CT or MRI scan also were performed in all patients, and we got all CT perfusion imaging figure. Then the CT perfusion imaging was analyzed with the CT or MRI scan.Result 1、Compared with control group, different changes had been found in the CT perfusion imaging figure of that 11 patients. 2、There were no differences in CBF figure and CBV figure between study group and control group, but there was marked difference in TTP figure between of them. 3、According to the changes of CT perfusion imaging figure, 11 patients had been divided into four stages. 5 patients were in I a stage, 3 patients were in I b stage, 1 patient was in II a stage, and 2 patients were in II b stage. But there was no dependability between the rate of artery stenosis and the stages of regional cerebral perfusion in pre-infarction period. Conclusion CT perfusion imaging is a sensitive technique to evaluate the changes of regional brain hemodynamics. And TTP is the most sensitive parameter.更多还原