【作者】 韩琳；

【导师】 毕荣修；

【作者基本信息】 山东中医药大学 ， 中医骨伤科学， 2007， 硕士

【摘要】 目的:观察关节止痛胶囊对膝骨性关节炎血清、关节液自由基水平的影响,并探讨其作用机理及膝骨性关节炎的发病机制。方法:将符合纳入观察标准的膝骨性关节炎的患者540例按随机化原则分为3组,分别为关节止痛胶囊治疗组180例、壮骨关节丸对照1组180例和维骨力对照2组180例。4周为一疗程,服药8周(两个疗程)后观察疗效。测定三组治疗前后血清、关节液超氧化物歧化酶(SOD)、一氧化氮(NO)含量变化,评价治疗疗效。结果:治疗后三组患者的血清、关节液超氧化物歧化酶(SOD)含量升高、一氧化氮(NO)含量降低,并且关节止痛胶囊治疗组作用较两组对照组明显。治疗组总有效率为83.89%,显效率为50.56%。结论:关节局部氧自由基、一氧化氮是引起膝骨性关节炎的重要介质;软骨细胞凋亡过盛可能是关节软骨退变的重要原因之一。关节止痛胶囊通过提高血清、关节液SOD含量,降低其NO含量,减少软骨细胞凋亡,有效改善了膝骨性关节炎患者的临床症状,恢复膝关节功能。更多还原

【Abstract】 Objective: To observe the effect of Guanjiezhitong capsule on free radical level in serum and articular fluid of Knee Osteoarthritis, and explore the possible mechanism of KOA. Methods: All 540 cases were randomly divided into three groups including treating group, control group 1 and control group 2. Each group include 180 cases. GuanJie ZhiTong capsule was used in treating group, ZhuangGuGuanJie pill used in control group 1,and Glucosamine Sulfate Capsules used in control group 2, the contents of NO、SOD in the serum and articular fluid specimens taken before treatment and 8 weeks after treatment were determined in every group and the total effective rate was observed.Results: The content of NO in the serum and articular fluid decrease, SOD enhance, and there was significant difference between treating group and control group. The total effective rate in treating group is 83.89%, and the apparent rate is 50.56%. Conclusions: Derived free radical and NO may play important roles in the developing process of KOA, Superfluous apoptosis of cartilage may be one of the pathway involved in the mechanism of articular cartilage degeneration. Because Guanjiezhitong Capsule can increase the content of SOD, decrease the content of NO in the articular fluids, reduce the apoptosis, it can improve the symptoms of KOA effectively and promote the repair of knee joint.更多还原