【作者】 王静；

【导师】 曹志群；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2007， 硕士

【摘要】 目的:研究和探讨昆参颗粒治疗进展期胃癌的疗效和作用原理。方法:1.将60例符合标准的进展期胃癌患者,随机分为昆参颗粒治疗组30例和参莲胶囊对照组30例进行临床疗效观察,同时比较两组的死亡率。2.实验研究用MNNG诱导出Wistar大鼠胃癌模型,随机分为阴性对照组、模型组、阳性对照组、昆参大、中、小剂量组,每组15只,比较给药后各组的微血管密度(MVD)情况。结果:临床研究昆参颗粒组治疗后有效率明显高于参莲胶囊组(P<0.05),治疗积分低于参莲胶囊组(P<0.05)。实验研究表明,昆参颗粒可明显降低诱导型胃癌荷瘤大鼠癌组织的微血管密度。结论:昆参颗粒可以降低胃癌组织的微血管密度,是治疗进展期胃癌的有效药物。更多还原

【Abstract】 Objective: Study the effect and principle of Kunshen Granule in treating progressive gastric carcinoma. Methods: 1. Clinical study: 60 patients who accorded with the diagnosis standard were separated to Kunshen Granule group and Shenlian Capsule group at random. We observed the clinical therapy result and compared the death rate of two groups. 2. Experimental study: Oral administration of MNNG to Wister rats resulted in a high incidence of gastric carcinoma. The rats were separated into six groups at random, negative control group, model group, positive control group, Kunshen large dose group, medium dose group and small dose group dose. After administration, we compared the count of microvessel density (MVD) of the six groups. Results: The clinical research proved that the effective rate of Kunshen Granule group was obviously higher than that of Shenlian Capsule group (P<0.05) and the therapy integral was lower than the Shenlian Capsule (P<0.05). The experimental research proved that Kunshen Granule could decline the MVD of carcinomatous rats experimentally induced. Conclusion: Kunshen Granule can decline the MVD of gastric carcinoma and treat the gastric carcinoma effectively.更多还原