【作者】 詹振林；

【导师】 谢树森；

【作者基本信息】 福建师范大学 ， 光学， 2007， 硕士

【摘要】 随着激光技术的发展，骨头等硬组织的激光消融在生物医学领域取得了越来越广泛的应用。鉴于光剂量选取在激光消融术中的重要性，本文从理论和实验上，初步开展了激光耳外科骨消融光剂量学的研究。首先，简要介绍激光在耳外科的应用情况和前景，概述激光骨消融光剂量学的国内外研究现状，阐述开展本论文的研究意义。其次，诠释生物组织激光消融的相关基本概念，探讨激光消融的相关机制，建立激光消融的组织模型和数学模型。然后从组织特性和激光参数两方面阐述激光消融中的光剂量学。再次，选用激光外科中最具代表性的超脉冲CO₂、脉冲Er：YAG和脉冲Ho：YAG三种激光对离体猪颞骨组织进行实验研究，分析比较不同激光能量密度下的消融效果，获得激光辐照产生的消融弹坑直径和消融深度随能量密度的变化关系，并分别确定三种激光对猪颞骨的消融阈值范围。最后，考察一维平移条件下连续CO₂激光对离体猪颞骨组织的消融效果，获得消融切口的宽度和深度随激光能量密度的变化关系，并对光学相干层析成像（OCT）和组织切片两种测量方法进行了分析比较。更多还原

【Abstract】 With the development of laser technology, laser ablation of hard tissue such as bonetissue is being used more and more widely for applications in bio-medical domain.Considering the importance of light dose in laser ablation, the research on light dosimetryof bone tissue ablation in laser ear surgery was developed preliminarily in theory andexperiment.Firstly, a short introduction to the situation and outlook of application of laser lightin ear surgery was briefly outlined. The status of light dosimetry of bone tissue ablationwas reported. Then the purpose to this study was also presented.Secondly, the basic concept related to bio-tissue ablation was given. The ablationmechanism related was discussed. The tissue model and numerical model of laser ablationwere established. Then based on tissue property and laser parameter, the light dosimetryof bone tissue ablation was illustrated.Thirdly, investigations on ablation of porcine temporal bone with pulse CO₂ laser,pulse Er:YAG laser and pulse Ho:YAG laser in vitro were presented. The ablation effectat different fluence was compared and analysed. The experiments obtained the trend ofcrater diameter and depth with energy density and found the ablation threshold for threelasers respectively.Finally, laser ablation of vitro porcine temporal bone was studied with continue CO₂laser, where bone tissue was moved along the line. The experiments obtained the trend ofcut width and depth with energy density. The measurements of cut depth with OCT andhistology were compared and analysed.更多还原