分子印迹复合膜的制备及其在药物分离上的应用

【作者】 张春静；

【导师】 钟世安；

【作者基本信息】 中南大学 ， 分析化学， 2007， 硕士

【摘要】 分子印迹技术(molecular imprinting technology，MIT)是一种使所得的聚合物的作用点对目标分子具有预定识别选择性的聚合物制备技术。该技术的基本原理为：首先模板分子在单一或混合的溶剂中通过共价或非共价作用与功能单体形成复合物；然后功能单体和交联剂在模板分子周围形成网状高分子聚合物；最后将模板分子从聚合物中洗脱或解离出来，这样聚合物上便留下了与模板分子在三维空间上匹配且带有特定功能基团的空穴，这些空穴对模板分子具有选择识别特性。基于分子印迹的特异识别性，近年来分子印迹膜技术显示出巨大的发展潜力，特别是分子印迹复合膜技术以其独特的物质识别与拆分技术优势，在催化、传感器、膜分离等方面都得到了很好的应用。本文主要就分子印迹复合膜应用于药物分离这一领域作了较为深入的研究。论文大致可分为两个方面：一方面以多孔醋酸纤维膜为基膜，分别以奎宁、萘普生、香兰素和EGCG为模板分子，采用表面修饰法制备了一系列具有分子识别能力且高选择性的分子印迹复合膜，并对膜的性能及分离识别机理等进行了探讨。另一方面，应用制备的分子印迹复合膜对结构相似药物以及中药中印迹分子进行了富集和分离，得到了比较满意的结果。该研究为药物分离及中草药中有效活性成份萃取提供了一个非常好的方法。分子印迹技术与膜技术相结合已在我们的生产中得到了广泛的应用。随着分子印迹技术的发展，其与膜技术的结合必将有更广阔的应用前景。更多还原

【Abstract】 Molecular imprinting is a technique empolyed for preparing polymers with synthetic recognition sites having a predetermined selectivity for analytes of interest. The principle of molecularly imprinting technology is described as Templates are first allowed to form complex with functional monomers by covalent bonds or non-covalent bonds in a solvent or mixed solvents. Subsequently functional monomers and crosslinker are cross-linked around templates. After polymerization, templates are removed from the polymers by extraction or dissociation, and leaving the specific cavities in regard to the shape and functionality. In recent years, based on the selectivity of molecular imprinting, the molecularly imprinting membrane technology has showed tremendous potential; especially, the molecularly imprinted composite membranes have been applied in some fields such as catalysis, sensors, membrane separation and etc due to its character of selectivity and separation.In this paper, we mainly go into the area of molecularly imprinted composite membranes as sorbents for enriching and separating pharmaceutical. The content of this paper includes two sides, one side is that the quinine、naproxen、vanillin and EGCG are employed as template molecule separatively, the molecularly imprinted composite membranes with high selectivity are prepared using the cellulose acetate as support by the method of surface modification, and the properties and separation mechanism of the membranes are discussed. The other side is that the obtained molecularly imprinted composite membranes are applied to enrich and separate pharmaceuticals from medicines with similar structure and Chinese traditional medicines, and satisfied results are acquired. The study may show a good method to separate medicines and extract an active component from Chinese traditional medicine.The combination of molecularly imprinting technology and membrane technology has been widely applied to our production. With the development of molecularly imprinting technology, this combination will acquire better applying prospect in the future.更多还原