2004年和2005年湖南省10家医院药物利用比较研究

【作者】 唐凌；

【导师】 谭红专；

【作者基本信息】 中南大学 ， 流行病学与卫生统计学， 2006， 硕士

【摘要】 目的：对湖南省10家医院各类药物利用情况及其发展趋势作出评价，其中对抗生素、心血管系统药物、抗肿瘤药物进行了重点分析。方法：利用金额排序和DDD_s分析法对湖南省10家医院2004年～2005年各类药物，其中重点对抗生素、心血管系统药物、抗肿瘤药物品种、金额、用药频度及限定日均费用进行统计分析。结果：2005年购药金额较2004年有较大的增长，但增长幅度呈减弱均势；抗感染药销售额两年均居首位，但2005年所占总金额的百分率有所下降；水、热量、电解质平衡药、内分泌系统药、呼吸系统药递增幅度较大。2004年～2005年湖南省10家医院抗生素使用呈增长的趋势，增长率21.66％；青霉素类、头孢菌素类和喹诺酮类抗生素的金额、品种数、DDD_s排序始终位列前3位；金额排序前20位的抗生素品种中，头孢菌素类占65％，青霉素类占20％；第四代头孢菌素使用金额增长最快；DDD_s排序前10位的抗生素品种波动较大。10家医院两年心血管系统药物购药金额与DDD_s均有大幅度增长；抗心绞痛药和周围血管扩张类药在心血管类药购药金额排名中比较靠前；DDD_s排序靠前的品种多为经济实惠、临床疗效较好、日均费用较低的常规药品。2004年～2005年抗肿瘤药物销售呈上升趋势；用药频度最高的为他莫昔芬，用药金额最大的为紫杉醇。结论：各类药物均有不同幅度的增长。抗生素使用金额呈上升趋势；青霉素类、头孢菌素类和喹诺酮类抗生素在抗生素使用中占主导地位；抗生素使用品种、金额波动变化较大；DDD_c值50元／日以下的中低价位抗生素在临床中应用最广。心血管药物应用广泛，安全、合理、有效、经济的使用是我们面临的重要课题，具有市场需求潜力及开发前景。抗肿瘤药物在医院占有重要地位，且逐年快速增长；抗肿瘤植物药将成为今后抗肿瘤药物治疗的方向之一。更多还原

【Abstract】 OBJECTIVE: To evaluate and analyze the current situation and tendendy of the various drugs use in 10 hospitals of Hunan province.,especially foxcu anti-infective agents, drug for cardi-ovascular system drugs, and antitumor drugs.METHODS: The medication data obtained from 10 hospitalsof Hunan province during the period from 2004 to 2005 were statistically analyzed kinds ofdrug, the total of money of drug purchase , dose; frequency of drug use and daily cost (DDDc) according to the DDDs and the sum order.RESULTS: The total amount of money for various drugs pruchase had been steadily increasing, but the growth rate has begun to decrease. The amount of money for purchase of anti-infective agents always ranked the first., but the percentage declined year by year, anti-malignancy drug, drug for cardiovascular system, and vitamins et al increased by a wide margin. The total costs of anti-infective agents used in 10 hospitals had increased 21.66% within two years, the consumption, kinds, and DDDs order of Penicillins, Cephalosporins, and Quenolones ranked first three places all the time, the forth cephalosporins had the most rapidly increasing. Anti-infective showed an large motion among first ten of DDDs order. The total costs and DDDs of cardiovascular drugs used in these hospitals increased sharply within two years. The consumption of antianginal and vasodilating agents ranked front places. Most of them had the more clinical efficient and less DDDc routine drug. The consumption of antineoplatic drugs during the period 2004～2005 showed an increasing tendency. Tamoxifen were used most frequently. Paclitaxel occupied the first place in the list of sum of money. CONCLUSIONS: The total amount of money for various kinds drug purchase has been steadily increasing. The cost of anti-infective agents tend to increase. The consumption of Penicillins, Cephalosporins, and Quenolones was the highest in the order of sum of money of antibiotics. Kinds and the sum of money of consumption of antibiotics motion.Largely. Less 50 yuan/day middle-low price antibiotics used widely in clinic. The reasonable, safe, and efficien of cardiovascular drugs utilization were important subject for us. Potential market requirement is enormous and exploitation prospect is wide for cardiovascular drugs.Antitumor drugs play an important part in the hospitals and increase quickly with years (the average annual incremental rate is 70.23%). Antitumor plant amedica would come main tendency for antitumor drug therapy in the future.更多还原