【作者】 徐旭军；

【导师】 张爱珍；

【作者基本信息】 浙江大学 ， 内科学， 2007， 硕士

【摘要】 代谢综合征(MS)是中心性肥胖、血糖异常、血脂紊乱及高血压多种危险因素在同一个体的聚结，可导致严重的心血管疾病及并发症。它属于多学科交叉的问题，病因和病理生理机制十分复杂，涉及遗传和环境因素，对代谢综合征的病因的探索已成为近年来的研究热点，流行病学调查研究显示不合理的饮食和生活方式是引起代谢综合征的重要原因。春节是中国最重要、最隆重的节日，习俗上放长假休息，大鱼大肉，可能导致代谢异常。目的：代谢综合征患者在春节期间血清磷脂脂肪酸谱的变化方法：研究对象为浙江大学华家池社区37例代谢综合征患者(男性21例，女性16例，年龄64.2±16.2岁)，代谢综合征采用2005年国际糖尿病联盟(IDF)颁布的全球统一的诊断标准。取2005年春节前一个月内和春节十五天后的血标本，采用气相色谱法测血清磷脂脂肪酸谱，酶法测定血浆血脂，葡萄糖氧化酶法测定血浆空腹血糖等临床指标。用SPSS12.0统计软件包进行统计学处理，P＜0.05确定为有显著性差异。结果：1．代谢综合征患者春节前后三酰甘油、空腹血糖和腰围有显著差异：代谢综合征患者春节后血浆三酰甘油、空腹血糖和腰围比春节前显著升高；春节前后血浆总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、血压、体重无显著性差异。2．代谢综合征患者春节前后血清磷脂脂肪酸谱无显著性差异3．代谢综合征患者临床生化指标与血清磷脂脂肪酸的相关性分析显示：血浆总胆固醇与C18：1、MUFA及n-3／n-6PUFA显著负相关；血浆三酰甘油与C16：0、C18：0、C18：2n-6、C20：4n-6、SFA、n-6PUFA及PUFA显著正相关；血浆低密度脂蛋白胆固醇与C20：0显著正相关；体重与C20：0显著正相关；收缩压与C22：0显著正相关。结论：1．代谢综合征患者在中国传统节日春节脂肪酸摄入比例无明显改变。2．代谢综合征患者应减少饱和脂肪酸的摄入，增加单不饱和脂肪酸和n-3多不饱和脂肪酸的摄入。更多还原

【Abstract】 The clustering of dysglycaemia, dyslipidaemia, hypertension and central obesity represent the major features of metabolic syndrome. Which may lead to cardiovascular disease and complication. The etiology of metabolic syndrome is very complicated, heredity and environment factors may play important role. The evidence from epidemiological studies showed that illegitimate diet and lifestyle are signigicant etiological factor. During Spring Festival, people gather together, consume more fat and alcohol, which may contribute to metabolic syndrome.OBJECTIVE: The aim of the present study was to determine the serum phospholipid fatty acid profile in patients with metabolic syndrome before and after the Spring Festival.METHOD: The clinical indicators of the 37 cases of MS patients (male: 21; female: 16 , aged 64.2± 16.2y) lived in Huajiachi community were determined before and after the Spring festival. The method for the determination is according to the standard by IDF (2005). And Gas chromatography(GC) was used to determine serum phosphohpid fatty acids from a month before the 2005 spring festival and 15 days after the festival, the blood plasma lipids was gained by enzyme method, and the limosis blood sugar was determinated by glucose oxidase method. We deal with the data by SPSS12.0 software and P<0.05 means the significant difference.RESULT: 1.The MS patients had a significant difference in triacylglycerol(TG)、 fasting blood glucose(FPG)、 waist circumference (WC). All of these index were raised significantly. And there wasn’t a significant difference in total cholesterol(TC)、 low density lipoprotein cholesterol(LDL-C)、 high density lipoprotein cholesterol (HDL-C)、 blood pressure (BP) and body weight (BW). 2.There wasn’t any significant difference in serum phospholipid fatty acids before and after the Spring Festival. 3. Bivariate correlate between biochemical indicator and serum phospholipids showed: there is a significant negative correlation between TC and C18:1、 MUFA、 n-3/n-6PUFA. And TG was significant positive correlate to C16:0、 C18:0、 C18:2n-6、 C20:4n-6、 SFA、 n-6PUFA> PUFA. LDL-C was also significant positive correlate to C20:0. BW was significantly negatively correlated with C20:0, and systolic blood pressure (SBP) was significantly negatively correlated with C22:0.CONCLUSION: 1.There is no significant variation in fatty acids profile during our traditional festival-the Spring Festival in MS patients. 2 The patients should reduce their SFA intake, increase n-3PUFA and MUFA.更多还原