【作者】 刘刚；

【导师】 刘进； 康焰；

【作者基本信息】 四川大学 ， 麻醉学， 2006， 硕士

【摘要】 目的：观察EPO是否能改善危重病人的贫血，降低输血率，减少输血量和医疗费用，以及改善病人的预后。 方法：采用前瞻性的随机对照研究。四川大学华西医院ICU病房70例病人，其中EPO组39例，对照组31例。对照组接受ICU的常规治疗，并常规补铁和维生素B₁₂；EPO组在对照组基础上加用EPO。病人在被纳入时进行APACHEⅡ评分。分别于第1、7、14、21、30天采外周静脉血测定红细胞（RBC）、血红蛋白（HB）、红细胞压积（HCT）、网织红细胞（RET）。第1～30天每天记录EPO组病人的血压。比较两组病人的年龄、性别、病因分类构成和第1天的APACHEⅡ评分、贫血相关指标。观察各项指标的变化趋势。比较两组的输血率、输血量、输血费用、ICU的停留时间、住院费用和死亡率。 结果：（1） 两组病人的年龄、性别、病因分类、第1天的APACHEⅡ评分和贫血相关指标比较均无统计学上的差异，说明两组基线一致，具有可比性。（2） 第30天贫血相关指标的比较显示：RET计数在EPO组和对照组之间有显著性统计学差异，P＜0.01。RBC、HB、HCT在EPO组和对照组之间均无统计学上的差异。（3） 组内贫血相关指标的比较显更多还原

【Abstract】 Objective: To explore wheather EPO would improve the anemia of critical ill patients, lower the ratio of blood transfusion , decrease the amount of RBC transfusion and lead to better clinical outcomesMethods: The prospective randomized control trial was used. In the ICU of west-China hospital, totally 70 patients were brought into the experiment and randomly divided into two groups （EPO group 39, control group 31）. Patients in the control group were given chalybeate and Vitamine B₁₂, besides receiving the routine therapy in ICU. The patients in EPO group used EPO on the basis of therapy in the control group. Aiming directly at the serverity of patient, the evaluation of APACHEII SCORE was made when each patient was taken in. Red blood cell（RBC）, hemoglobin （HB）, haematocrit（HCT）, reticulocytes（RET） in the blood were measured at the 1st, 7th, 14th, 21st, 30th day. Blood pressure of each patient in EPO group was recorded once everyday. These parameters were compared between two groups such as age, sexuality, classification of etiological factor, APACHEII SCORE, and更多还原