【作者】 薛建英；

【导师】 陈国良；

【作者基本信息】 沈阳药科大学 ， 药物化学， 2004， 硕士

【摘要】 本文对抗过敏药的作用机理、分类、作用特点及其发展概况作了简述，对新型抗过敏药盐酸奥洛他定的合成工艺进行了研究。 本文对抗过敏药盐酸奥洛他定的合成路线进行了比较分析，以降低反应成本，简化操作为目标，选取了一条比较合理的合成路线，经七步反应，一步柱层析分离，合成了盐酸奥洛他定。并对五步反应进行了研究，降低了成本，使操作更简化，安全，总收率为4.2％。 奥洛他定的化学结构经~1H-NMR，MS及IR确证。更多还原

【Abstract】 The mechanisms and development of antiallergic drugs were briefly reviewed in this thesis, in which olopatadine hydrochloride, as a new antiallergic drug was introduced, olopatadine hydrochloride is an inhibitor of the release of histamine from the mast cell and a relatively selective histamine H₁-antagonist, It is devoid of effects on alpha-adrenergic, dopamine, andmus carinic type 1 and 2 receptors. So the side-effect is small.The synthetic methods of olopatadine hydrochloride were discussed and optimized, 7-step synthetic route was chosen in the thesis. In order to decrease the cost, simplify the operating procedure, 5-step reaction conditions were investigated intensively. The total yield reached 4.2%.The structure of olopatadine was determined by ¹H-NMR,MS and IR.更多还原