【作者】 张婧；

【导师】 王东梅；

【作者基本信息】 山东中医药大学 ， 中医妇科学， 2006， 硕士

【摘要】 目的:探讨补肾抑抗汤配合避孕套隔绝疗法治疗女性免疫性不孕(抗精子抗体阳性)的疗效和作用机理;比较原因不明性不孕症患者中宫颈粘液AsAb和血清AsAb的阳性率。方法:对130例原因不明性不孕症患者检测宫颈粘液AsAb和血清AsAb;将检测出的52例血清和/或宫颈粘液AsAb(+)患者随机分为治疗组(26例,口服补肾抑抗汤,同时用避孕套隔离)及对照组(26例,仅用避孕套隔离),观察治疗前后临床症状改善情况、宫颈粘液及血清AsAb转阴情况,监测妊娠结果。结果:宫颈粘液AsAb阳性率高于血清AsAb,差异有显著性(P<0.05);治疗组与对照组比较,在改善临床症状、抗体转阴率、妊娠率、复发率方面差异均有显著性(P<0.01或P<0.05)。结论:宫颈粘液AsAb的检测在诊断免疫性不孕症中有重要作用;补肾抑抗汤可有效调节患者的免疫功能,改善临床症状,显著提高抗体转阴率及妊娠率,降低复发率。更多还原

【Abstract】 Objective To explore the effect and mechanism of treating immunological infertility with positive cervical mucus or/and serum antisperm antibody (AsAb) by Bushenyikang Decoction in combination with isolation therapy; to compare the positive rate of cervical mucus AsAb and serum AsAb in patients with infertility of no significant etiology. Methods To assay the cervical mucus AsAb and serum AsAb in 130 patients; 52 patients with positive cervical mucus AsAb or/and serum AsAb were divided randomly into the treatment group(26 cases, treated with Bushenyikang Decoction in combination with condom) and the control group(26 cases, treated with condom only). Observe the improvement of clinical symptoms and the pregnant outcome. Results The positive rate of cervical mucus AsAb is higher than that of serum AsAb with significant difference(P<0.05); there was significant difference between the two groups in the relief of clinical symptoms, rate of AsAb turning to negative, pregnant and recurrent rate(P<0.01 or P<0.05). Conclusion The assay of cervical mucus AsAb is of important value in diagnosing immunological infertility; Bushenyikang Decoction can effectively modulate patients’immunological function, improve clinical symptoms, and significantly enhance the turning-to-negative rate and pregnant rate.更多还原