【作者】 李蕾；

【导师】 孙忠人；

【作者基本信息】 黑龙江中医药大学 ， 针灸推拿学， 2006， 硕士

【摘要】 目的: 通过对比观察针药结合治疗血瘀型原发性三叉神经痛的可行性及有效性评价,旨在为血瘀型原发性三叉神经痛寻求一种疗效确切、持久而副反应少的临床治疗模式。 方法: 1 按中药新药临床研究指导原则的要求,采用专家评分法,根据主症和次症在证候诊断中的作用,确定其权重和进行可靠性评估。然后,判断病情的轻、中、重程度,制定症状分级量化表。 2 选择60例符合入选标准的患者,随机分成治疗组及对照组,治疗组给予针药结合治疗;对照组给予常规卡马西平治疗,疗程均为一个月。 3 采用了Huskisson“视觉模拟评分法(VAS)”和制定的症状分级量化表进行治疗前后积分比较,得出疗效评价。 结果: 1 临床研究表明,两组在VAS疼痛改善程度相比,无显著性差异,疗效相当(p>0.05)。 2 两组症状量化积分总疗效比较,无显著性差异,疗效相当(p>0.05) 3 治疗组在消除兼证的疗效上明显优于对照组(p<0.05)。 结论: 1 制定的血瘀型原发性三叉神经痛症状分级量化标准稳定可靠。 2 制定的血瘀型原发性三叉神经痛症状分级量化标准,为中医治疗TN(原发性三叉神经痛)研究的规范化奠定了基础 3 针刺加自拟汤药治疗能有效解除或缓解疼痛,明显消除不寐,情绪抑郁或烦躁不安等兼证,其止痛效果与西药卡马西平的更多还原

【Abstract】 Objective:The present study is designed to explore the availability and effective evaluation of acupuncture combined with decoction in treating primary Trigeminal Neuralgia in blood stasis syndrome through contrasting with clinical therapy between acupuncture combined with decoction and Carbamazepine and to find a method of well stable efficacy and few side-effects .Methods:i)Applying the method of experts’ evaluation, screening the main clinical indexes according to instructive principle of clinical study on traditional and new Chinese medicine, defining their weight and making estimation about their reliability based on the contribution of main and minor symptoms, then judging patient’s condition and classifying into three grades: light, middle and severe, making the symptomatic grading and quantifying standards, ii) 60 patients are divided into two groups at random: therapy group and control group, cases in therapy group are cured with acupuncture combined with creative decoction;cases in control group are treated with Carbamazepine. The course of treatment is 30 days.iii) Evaluation of efficacy is made by comparing visual analog pain scores and quantificar scores of symptoms between pre-treatment and post-treatment Result:The clinical observations show that the difference between the two groups is insignificant at the aspect of improving VAS Scores and quantificar scores of symptoms(p>0.05).And there is a very significant difference in curing the minor symptoms between the two groups (p<0.05). The results show that acupuncture combined with creative decoction has the same effect as Carbamazepine. ConcIusion:The effect of acupuncture combined with creativedecoction in treating primary Trigeminal Neuralgia in blood stasis syndrome is persuasive, furthermore it prefers to Carbamazepine in improving the minor symptoms. It has safety and little side-effects. The making of symptomatic grading and quantifying standards is stable and reliable. It provides the basis for the standardization of clinical study on TN更多还原