【作者】 周慧；

【导师】 张爱伦；

【作者基本信息】 新疆医科大学 ， 老年医学， 2005， 硕士

【摘要】 目的:观察老年高血压合并脑血管病患者动态血压的特点。方法:对74例高血压合并脑血管病患者及77例单纯高血压病患者进行24小时动态血压监测。结果:高血压合并脑血管病患者24小时平均血压、白天平均收缩压、夜间平均血压均高于单纯高血压组,两组相比有差异性(P<0.05)。24小时血压标准差两组相比差异无显著性。70%高血压合并脑血管病患者血压昼夜节律消失,而单纯高血压病患者41%血压昼夜节律消失(P<0.05)。高血压合并脑血管病患者81%出现晨峰现象,而单纯高血压组42%出现晨峰现象(P<0.05)。结论:血压水平尤其是收缩压水平影响老年高血压病患者脑血管病的发生,血压昼夜节律变化和晨峰现象也与高血压合并脑血管病相关。高血压合并脑血管病患者晨峰现象增加,血压昼夜节律消失增多。恢复血压昼夜节律和降低晨峰血压对于预防老年高血压病患者心、脑血管事件是一个新的治疗目标。更多还原

【Abstract】 Objective: To observe the characteristic of ambulatory blood pressure of patients with elderly hypertension with cerebrovascular disease. Methods: 74 elderly hypertension with cerebrovascular disease and 77 simple hypertension were undergone 24h ambulatory blood pressure monitoring. Results: 24hSBP, 24hDBP, dSBP, nSBP, nDBP difference in 2 groups(P<0.05). 24h blood pressure variability did not differ between the two groups. The circadian rhythm in 70% of the patients with hypertension with cerebrovascular disease while that in 41% of the patients with simple hypertension disappears (P<0.05). Morning surge arose in 81% of the patients of hypertension with cerebrovascular disease compared with 42% of the patients with simple hypertension(P< 0.05). Conclusion: blood pressure especially systolic blood pressure has direct connection with cerebrovascular disease. The changes of circadian rhythm and morning surge are closely related to hypertension with cerebrovascular disease in elderly hypertensive patients. Morning surge increases obviously and circadian rhythm significantly disappears in patients with hypertension with cerebrovasculur disease. Recovery circadian rhythm and reduction of the morning surge could thus be a new therapeutic target for preventing target organ damage and subsequent cardiovascular events in elderly hypertensive patients.更多还原