睡眠呼吸暂停综合征与心血管疾病

【作者】 赵艳；

【导师】 戴万亨；

【作者基本信息】 成都中医药大学 ， 中西医结合临床， 2005， 硕士

【摘要】 睡眠呼吸暂停综合征(sleep apnea syndrome,SAS)根据发病机制不同分为:阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)和中枢性睡眠呼吸暂停(central sleep apnea,CSA)。 睡眠呼吸暂停(sleep apnea,SA)与心血管疾病(cardiovascular disease,CVD)关系密切。SA通过低氧、胸内压改变及交感神经和副交感神经活性失衡等病理生理改变,导致一系列心血管疾病包括高血压、冠心病、心律失常、心力衰竭甚至猝死。同时,心力衰竭也可成为SA发生的原因或启动因素(主要是CSA),而CSA的出现又可明显促进心衰的进展,增加患者死亡率。近年来众多的研究信息还提示SA通过代谢、血管因素、血液系统、基因标记等途径来增加CVD的危险。目前认为SA与CVD相互影响,但其中的具体机制,SA是否为CVD的独立危险因素,是否治疗SA即可降低CVD患病率等还不完全清楚。中医对SA病机有一定的认识,治疗方面也积累了一定的经验,但其中还存在诸多问题有待进一步解决。本文通过对SA与CVD的探讨提出了SA与CVD关系研究的新方向及中医诊治SA还需明确的问题。更多还原

【Abstract】 Sleep apnea syndrome (SAS) includes obstructive sleep apnea syndrome(OSA), central sleep apnea syndrome(CSA). OSA is the most common, with an incidence man and woman of 4% and 2%, respectively. Major risk factors for OSA include obesity, male gender, increasing age and abnormal of craniofacial morphology. OSA as the most extreme variant is characterized by intermittent episodes of the up airway during sleep that disrupt normal ventilation and sleep architecture and is typically associated with snoring and daytime sleepiness. With the research development of OSA, there are increasing information indicated that OSA have important relationship with cardiovascular disease(CVD) and that OSA via various mechanisms increase CVD morbidity and mortality. However, many risk factors for OSA, such as obesity and male gender, are the same as for hypertension and CVD. Thus, only recently has there been converging evidence that OSA is a risk factor for their development. Moreover, there is increased data show that OSA is linked to metabolic, vascular, hematology and genetic markers associated with increased risk of CVD. In addition, CSA mainly results from heart failure, otherwise appears to be an important factor that influences morbidity and mortality among those patients. Nevertheless, responsible mechanisms, the role of sleep apnea (SA) as a risk factor "independent" of associated morbidities and whether treatment of SA will mitigate this are unknown and remain to be determined. Traditional Medicine has some experience in treating SA but there are still many problems undetermined.This article discusses SA and CVD and brings forward new research directions of the relationship of SA and CVD and the problems that Traditional Medicine faced.更多还原