【作者】 孙冬玮；

【导师】 孙忠人；

【作者基本信息】 黑龙江中医药大学 ， 针灸推拿学， 2005， 硕士

【摘要】 目的:探讨抑郁症的神经生物学发病机制,揭示针刺治疗抑郁症的机理。 方法:以Wistar大鼠为受试对象,采用给予孤养大鼠以长期不可预见的中等强度刺激的方法建立抑郁大鼠模型,检测了应激后造成的抑郁模型大鼠行为学改变、下丘脑—垂体—肾上腺皮质轴(hypothalamus—pituitary—adrenocorticalaxis HPA)的变化,同时观察了针刺对其的干预作用,并进行了不同针法的疗效比较研究。 结果:模型组、生理盐水组与正常对照组相比血清CORT和ACTH含量升高明显;手针治疗组、电针治疗组与模型组相比血清CORT和,ACTH含量下降明显;药物组与生理盐水组相比血清CORT和ACTH含量下降明显,与手针治疗组、电针治疗组比无明显差别。 结论: 1.针刺可使抑郁大鼠活动增多、兴趣提高、快感增加、食欲增加。 2.进一步证实HPA轴功能亢进是抑郁症的病理改变之一。 3.针刺对HPA轴功能具有双向调节作用,针刺可以拮抗抑郁。症亢进的HPA轴功能,使其趋于正常。更多还原

【Abstract】 Objective: To reveal the mechanism of treating depression with acupuncture and explore the physiopathology mechanisms of depression .Methods: Forty-two male Wistar rats were randomly divided into six groups of 7 each .All rats except the control group singly housed and exposed chronically 21 days to a variety of moderate unpredictable stressors to form rat model of depression .Use open-field test to observe depressive rat’s behavioral change; use biochemical method to observe the effect of acupuncture on hypothalamus-pituitary-adrenocortical axis of depressive rats. And the curative effects with different acupuncture therapy methods were compared.Result: acupuncture can improve abnormal behavior of depressive rats ; acupuncture can diminish HPA axis responsivity of depressive rats. Acupuncture is a simple and effective method for treating depression.更多还原