【作者】 郑建斌；

【导师】 霍小林；

【作者基本信息】 中国科学院研究生院（电工研究所） ， 电工理论与新技术， 2005， 硕士

【摘要】 经颅磁刺激是一种利用时变磁场产生感应电流刺激大脑的技术。现在已经广泛地应用于精神疾病治疗及脑功能的研究。但是,在真正将TMS 用于临床治疗之前,还需要做大量的动物实验。国内外许多实验都报道了TMS 的治疗效果。但是,由于大鼠的大脑较小,因此往往整个皮层同时达到阈值。很难将动物的实验的结果推广到人体上去。因此,有必要了解动物大脑中真实的感应电场分布情况。本文首先在分析了感应电场计算理论的基础之上,系统地阐述了刺激线圈的设计和制作的方法,并设计了一套用于评价线圈绕制质量的感应电场测量系统。其次,针对现在的感应电场计算模型都是用人体模型,而没有动物模型的情况,本文结合了三维重构技术和有限元方法建立了大鼠真实头模型感应电场分布的计算方法。该方法可以用于经颅磁刺激实验的设计和实验结果的解释。最后,经仿真比较给出了适合于大鼠经颅磁刺激实验的线圈参数和放置位置,用于指导实际的经颅磁刺激实验方案的设计,以提高实验效率。更多还原

【Abstract】 Transcranial magnetic stimulation (TMS) is a non-invasive technique that uses the principle of electromagnetic induction to generate currents in the brain via pulsed magnetic fields. Now it has been widely used in the treatment of psychiatric and brain research. But, before TMS is put into clinical trial, many TMS experiments are undertaken on rats. There have been some promising diagnostic and therapeutic results of TMS on rats. However, rat brains are much smaller than human brains, so the magnetic coil used for human beings would affect more rat brain areas than human brain areas. Therefore, it is necessary to analyze the exact electric field induced by TMS on rat brains. Firstly, the design and construction methods of the stimulating coil were demonstrated in detail on the basis of the analysis of electromagnetic theory. Further, a measurement system of the induced electric field has been designed and built to evaluate the quality of the coil. Secondly, since the computational model of electromagnetic fields have not been applied to the animal at present, a computational method of induced electric fields in the real rat’s head model during transcranial magnetic stimulation is presented with the help of 3D reconstructing technology and finite element methods. This method is quite useful to design TMS experiments on rats and interpret results of these experiments. Finally, this paper proposes both parameters of the stimulation coil and its position, which are appropriate for TMS experiments on rats. With the help of these results, design of TMS experiments on rats will be much easier and outcomes of these experiments will have more well-founded explanations.更多还原