【作者】 黄骁；

【导师】 李智贤；

【作者基本信息】 广西医科大学 ， 影像医学与核医学， 2005， 硕士

【摘要】 目的: 应用经直肠超声(TRUS)观察光子治疗良性前列腺增生症(BPH)前后前列腺的超声表现,研究TRUS评价光子治疗BPH疗效的价值,确定并完善BPH非手术治疗的疗效评价指标体系。方法: 30例重度BPH患者应用Dolphin-2000 前列腺光子治疗机治疗进行治疗,采用经直肠彩色多普勒血流显像对治疗前、治疗后一个月、治疗后六个月的前列腺进行观察,测量其体积、内外腺厚度之比、移行带指数(TZI)、尿道前列腺动脉收缩期峰值速度(Vs)、阻力指数RI、血管内径(D),各项指标数据经SPSS 10.0统计软件处理,各项指标间用Pearson相关进行两两相关分析,分析其统计学意义,以确定超声评估光子治疗前列腺增生症的疗效有关指标。结果: 治疗一个月、六个月后, 复查经直肠超声,其中3例各项指标改变均不明显,27例前列腺(内腺)体积、内外腺厚度之比、移行带指数(TZI)、尿道前列腺动脉收缩期峰值速度(Vs)、阻力指数(RI)、血管内径(D)于治疗后均有显著下降(P<0.05,P<0.001)。各项指标间具有很好的相关性,与国际前列腺疾患症状评分(IPSS)及国际前列腺疾患排尿症状对生活质量影响的评估(QOL)相符合(显效18例,好转9例,较差3例)。结论:经直肠超声可为良性前列腺增生症光子治疗效果评价提供更多还原

【Abstract】 Objective: To investigate the Ultrasound findings of thebenign prostate hyperplasia (BPH) before photon Therapy andpost-treatment and study the clinical value of TransrecctalUltrasound in evaluating Therapeutic Efficacy on photonTherapy for BPH. For the more,To give the objective indexesand consummate the evaluation index system of the curativeeffect on non-operation therapy for BPH.Methods: In order to carry out Prostate photon treatmentsystem irradiation, the active area of the applicator waslocated into rectum in 30 patients with brachytherapy, eachcase was observed by transrectal color Doppler flow imagingpre-treatment and post-treatment for one month and six months.These indexes such as the prostatic volume ,nnergland/extragland thickness ratio and TZI ,the systolicvelocity(VS), RI and diameter of innergland artery weremeasured. Each index data was analyzed statistically bySVSS10.0 and Pearson software. then find the evaluation indexsystem of the curative effect on non-operation therapy for BPHby Ultrasound.Results: After one month and six months treatment , Theprostatic volume ,innergland/extragland thickness ratio andTZI and the systolic velocity(VS), RI and diameter ofinnergland artery were significantly decreased in 27 cases,and 3 cases without change.18 cases were remarkably improved,9 cases were slightly improved on IPSS,QOL,volume of prostategland Qmax and residual urine before and after therapy(besidesQmax P=0.038 , all other are P<0.01) and 3 cases wereineffective. the index correlated well with each other, Thatindicates the prostatic volume , innergland/extraglandthickness ratio and TZI and the innergland hemodynamics iscorresponded with clinical change.Conclusions: The Therapeutic Efficacy of Finaste ride onphoton Therapy for BPH can be evaluated by several objectiveindexes.The prostatic volume,innergland/extragland thicknessratio and TZI are morphology index,The systolic velocity(VS),RI and diameter of innergland artery are hemodynamic index .Good correlation was shown between the objective indexes andsubjective indexes (IPSS,QOL).If they were combined together,it can consummate the evaluation index system of the curativeeffect on non-operation therapy for BPH. We think TRUS cancontribute more quantitative information to evaluate theresults post Therapy for BPH. TRUS is a noninvasive, safe,accurate and repeatable method and is valuable for wide-spreadapplication.更多还原