【作者】 杨扬；

【导师】 宋爱莉；

【作者基本信息】 山东中医药大学 ， 中医外科学， 2005， 硕士

【摘要】 目的:观察消癥丸对气滞痰凝血瘀型乳腺增生病的治疗效果,并探讨其作用机理。方法:本试验为双盲双模拟、阳性药物平行对照的临床研究。68例气滞痰凝血瘀型乳腺增生病患者随机分为2组,揭盲后统计消癥丸组36例,乳结康丸组32例。前组予消癥丸和乳结康丸模拟药,后组予乳结康丸和消癥丸模拟药。4周为1疗程,经期停服,治疗2个疗程后,对两组治疗前后主要症状、体征、辅助检查和疗效指数评价。结果:消癥丸组显效3例,有效28例,无效5例,总有效率86.11%,乳结康丸组显效2例,有效24例,无效6例,总有效率为81.25%,两组总体疗效相当。主要症状(乳房疼痛)积分和血液流变学中血浆粘度、纤维蛋白原指数改变,消癥丸组明显优于乳结康丸组(P<0.01或P<0.05)。结论:中医认为乳腺增生病主要病机为肝郁脾虚,肾虚冲任失调,以致气滞痰凝,瘀血阻络、经络不利,痰瘀互结,且气郁日久可化火,阳明内热及肝郁化火致气血津液搏结不畅而成痰瘀。肝郁脾虚、肾虚冲任失调为发病之本,气滞痰凝血瘀胃热为发病之标。标本虚实互为因果,相互转化,因此本病治疗最宜辨证论治,标本兼顾。消癥丸针对主要病因病机,在疏肝理气、活血化瘀、软坚散结的基础上,加重清泄胃热、活血化瘀,对改善患者乳房疼痛及血液流变学指标作用显著,是治疗乳腺增生病的有效药物。更多还原

【Abstract】 Objective:To observe the clinical effect of the drug Xiaozhengwan on hyperplasia of mammary gland and discuss its therapeutic mechanisms.Methods:68 cases were divided into Xiaozhengwan group (36 cases)and Rujiekangwan group (32 cases)randomly. The changes of primary clinical symptoms and signs in all cases were observed and given evaluation after two periods of treatment.ResuIts: The gross curative effect in two groups were correspond after treatment.The improvement of primary clinical symptoms,the changes of blood rheology of Xiaozhengwan group were obviously better than that of Rujiekangwan group(P<0.01 or P<0.05). Conclusion:Xiaozhengwan is a effective drug to cure HMG.lt can significantly improve primary clinical symptoms and blood rheology condition.更多还原