【作者】 张涛；

【导师】 谢延风；

【作者基本信息】 重庆医科大学 ， 神经外科学， 2005， 硕士

【摘要】 益智药奥拉西坦是一种环 GABOB 衍生物,它是一种能促进学习,增强记忆力,保护受损神经细胞的中枢神经系统药物。目前其研究主要在神经系统退化性疾病方面,如老年性脑功能不全综合征,老年性痴呆,脑动脉硬化症,脑血管意外所致记忆和思维能力的减退等。但在脑外伤方面的研究则较少,由长沙怀恩医药研究所开发的奥拉西坦注射剂在全国五大医院进行了多中心双盲三期临床实验。我们采用神经电生理检查对奥拉西坦治疗轻中型脑外伤的疗效进行研究,以弥补其疗效评估的不足。 目的:通过神经电生理监测,探讨益智药奥拉西坦对轻中型脑外伤的疗效。方法: 采用随机双盲阳性药物对照试验,定量脑电图检查的轻中型脑伤的对照组和治疗组病人各 24 例;P300检查的轻型脑伤的对照组和治疗组病人各 20 例。分别于用药前、用药21 天完毕后进行定量脑电图和 P300 数据采样,然后对吡拉西坦组和奥拉西坦组用药前后的数据进行配对 t 检验,以分析两组用药前后的定量脑电图和 P300 差异;对两组用药前后的定量脑电图和 P300 差值进行两样本 t 检验以分析差异。结果:两组病人用药前后的定量脑电图和 P300 参数都有差异(P<0.001),即两组药物均有效;两组病人用药前后的定量脑电图和 P300 参数差值有差异(P<0.05、P<0.001),即奥拉西坦组较吡拉西坦组的效果更好。 结论 定量脑电图和 P300 的改变更多还原

【Abstract】 Nootropics oxiracitam is a kind of loop-GABOB ramification, whichbelongs to central neuronal system(CNS)drug. Oxiracitam can promotelearning,enhance memory and protect nerve cells. At present, the studyabout oxiracitam is mostly focused on CNS degenerate disease, such asaged cerebral function-deficience syndrome, Alzheime’s disease, cerebralatherosclerosis and the reduced memory and ideation after cerebrovascularattacking. But the studies of oxiracitam effect traumatic brain injury(TBI)are still lacking. The oxiracitam injection producted by Chang Sha HuaiEng Medical Research Institute are operated on the multicenterdouble-blind clinical test of third period in five domestic hospital. Weadopted neuroelectriphisilogical measure to investigate the curative effectof oxiracitam treating the mild and moderate TBI. The aim of our study isorder to remedy the scarcity in this domine. abjective: To reveal theeffects of nootropics oxiracetam treat the light and midding TBI bymonitoring of . neuroelectriphisilogical measure. Methods: The randomdouble-blind contrast test is applied. The piracetam group and oxiracetamgroup are both 24 mild and moderate TBI patients in qEEG test. And Thepiracetam group and oxiracetam group are both 20 mild TBI patients inP300 test. We apartrespectively collect the data of qEEG and P300 beforegiving medicine and after 21 days of the end of treatment. Then thedifference of the data of qEEG and P300 between the beginning and theend of giving piracetam and oxiracetam will be analyzed by paired t-test.The difference of the discrepant data of qEEG and P300 between piracetamgroup and oxiracetam group will be analyzed by two-sample t-test. Result:The discrepancy of the data of qEEG and P300 between the beginning andthe end of giving this two medicines is proved existent(P<0.001), that’s tosay this two medicine are beneficial to the patients’ treatment. Thedifference of the discrepant data of qEEG and P300 between two group isproved existent(P<0.05, P<0.001), that’s to say the effect of oxiracetamgroup is more obvious than piracetam group. Conclusion: The change ofqEEG and P300 proved that oxiracetam can promote the recovery of thelight and midding TBI, and the efficacy is better than piracetam.更多还原