【作者】 朱亮；

【导师】 吴华香；

【作者基本信息】 浙江大学 ， 内科学， 2005， 硕士

【副题名】A Report of 21 Cases

【摘要】 目的:探讨混合性结缔组织病(MCTD)患者临床特点,并对6例出现肺动脉高压朋市间质病变以及5例出现肾脏损害患者的临床特点和意义进行回顾性分析。 方法:回顾性调查21例患者年龄、性别、病程以及各种临床特点和实验室检查,并对结果进行分析。 结果:MCTD最常见的临床表现为雷诺现象,其次为发热、关节肿/痛和肌炎,有肺间质病变朋市动脉高压的患者肌炎和硬指/手指肿胀的出现率高;对于MCTD患者,需早期进行肺部HRCT的检查,排除有无肺间质病变的出现。男性患者常以肾脏的累及为首先或主要表现,病程较短,进展较快,女性患者肾脏累及较男性少见,累及者病程较长,一旦累及肾脏,男女患者最后均可出现肾功能不全。更多还原

【Abstract】 Objective: To evaluate the clinical features and correlation with disease course of mixed connective tissue disease (MCTD). The clinical features of 6 patients with pulmonary artery hypertension / pulmonary interstitial fibrosis and 5 patients with kidney lesion secondary to MCTD were reported and literature were reviewed.Methods: 21 patients with definite MCTD were analyzed retrospectively by their clinical manifestation and immunological features and treatments.Results: The primarily incipient symptoms of MCTD were Raynaud’s phenomenon, the next symptoms were febrile、 arthralgia/ arthritis and myositis. Myositis and sclerodactyly/finger swollen were easy to be seen in patients with pulmonary artery hypertension / pulmonary interstitial fibrosis. Earlier lung HRCT is help to diagnosispulmonary interstitial fibrosis. Kidney lesion is less than male in female.Those who suffer kidney lesion tend to renal function failure.更多还原