【作者】 杨文波；

【导师】 戈延茹；

【作者基本信息】 延边大学 ， 药剂学， 2004， 硕士

【摘要】 目的：根据药物经济学的原理，通过对住院患者住院期间与门诊患者治疗消化性溃疡用药方案的分析和比较，阐明治疗消化性溃疡可划分为几个时段，按时段治疗的观点指导治疗，可获得最为经济、效果最好的药物治疗。为临床选择最佳时段性用药的观点提供理论依据。 方法：1、划分治疗时段，2、对有意义的时段进行用药比较，3、对治疗时段用药分析采取的是：收集消化性溃疡住院病历，按照临床用药方案进行分组，A组为西咪替丁600mg+甲硝唑500mg+其它抗生素每日二次静点；B组为泮托拉唑40mg+甲硝唑500mg+其它抗生素每日一次静点；C组为奥美拉唑40mg+甲硝唑500mg+其它抗生素每日一次静点。D组为门诊治疗对照组奥美拉唑20mg+克拉霉素500mg+甲硝唑400mg每日二次口服一周。应用SPSS统计软件比较各组间治疗结果及用药费用是否具有显著性差异。从用药的时段上、方便程度、用药疗程上综合评价用药方案的合理性。 结果：患者在住院期间无论选择哪种治疗方案成本、效果间，均无统计学上的差异，而门诊患者的治疗费用明显低于住院患者的治疗费用。 结论：临床应重视门诊患者的治疗，将消化性溃疡控制在这一时段，以最小的用药成本达到最大的治疗效果，用药方便、省吋，节约卫生资源。更多还原

【Abstract】 Objective: In order to provide some theoretical bases for the clinicians to choose the best therapeutical scheme and a given period of time for the patients who contract peptic ulcer , according to the principle of pharmacoecnomics, we have explored and analyzed the rationality of the prescriptions by comparing between the therapeutical scheme of inpatients and outpatients in the two given period of time. We expound the view that can gain the most economical and the best effectiveness according to a given period of time cure peptic ulcer. Methods: 1, Dividing a given period of therapeutical time, 2, Compering a given period of significant time, 3, Collecting the cases of inpatients to divide them into groups by the simi larity of the prescriptions, Group A is 16 cases of prescriptions of Cimetidine600mg+Metronidazole 500mg-The other Antibiotics for injection bid; Group B is 26 cases of prescriptions of Pantoprazole40mg+Metronidazole 500mg+The other antibiotics for injection qd; Group C is 13 cases of prescriptions of Omeprazole40mg+Metronidazole 500mg+the other Antibiotics for injection qd. Group D is Omeprazole20mg+Clarithromycin500mg +Metronidazole400mg bid 1wk po 3, Comparing the effects and costs of the groups and seeing if there are some remarkable differences, or evaluating comprehensively the rationality of drug-use from convenience and a given period of time. Conclusion: There is no difference whichever the inpatients scheme between their effectiveness and costs , but the cost of outpatients is lower than that of inpatients , we should emphasize on outpatients to control the peptic ulcer in the period of time and to find the way which can get the best result in use less money, convenient way and a short time in order tosave our medical resources.更多还原