良性前列腺增生症中医证型与组织形态学表现的相关性研究

【作者】 刘利华；

【导师】 张亚大；

【作者基本信息】 南京中医药大学 ， 中西医结合临床， 2004， 硕士

【摘要】 目的 了解BPH中医证型与组织形态学相关性的流行病学情况。 方法 按照南京大学出版社1994年出版的《中医病证诊断疗效标准》对100例临床诊断为BPH的患者中医辨证为六个证型，同时分析其IPSS(国际前列腺症状评分)、症状评定等相关因素。对手术获得的前列腺组织标本用光学显微镜进行组织形态学(结节状增生、不典型增生、前列腺上皮内肿瘤、前列腺癌)观察。应用SPSS10.0进行统计，卡方检验。 结果 ① 肾虚证、血瘀证和湿热证三型患者共占总数的81％，与其余两证型相比有极显著性差异，u=8.768，P＜0.01。② 血瘀证患者的年龄与肾阴亏虚证、中气下陷证两组相比有显著性差异(P值分别为0.037，0.002)，血瘀证前列腺重量与中气下陷证比较，有显著性差异(P=0.018)。另外，前列腺重量与年龄有显著相关性，相关系数为0.26，p=0.021。③ 组织形态学与年龄的P为0.01，认为PIN(前列腺上皮内肿瘤)组的年龄与结节状增生和不典型组之间均有显著性差异(P＜0.05)。PIN组与结节状增生组的前列腺重量比较也有显著性差异(P=0.03)。结果表明，气滞血瘀证和PIN在年龄、前列腺重量两方面在与各自组别的比较中均有显著性差异，而气滞血瘀证中PIN的百分比与其他证型相比有显著性差异，P＜0.01。据此认为本组资料BPH中的PIN可能与气滞血瘀证相关。 结论 本组资料BPH中的PIN可能与气滞血瘀证相关。但临床上两者是否有密切相关，有待进一步的深入研究。更多还原

【Abstract】 Objective To investigate the correlation of TCM(traditional Chinese medicine ) types of BPH and types of prostatic histology.Methods Based on the standard of the diagnosis and effect of TCM disease published 1994 year by Nan jing university publishing company, 100 cases of BPH(clinical diagnosis) were divided six syndromes. Other clinical parameters (IPSS, chief complaint parameters ) were also collected. Prostatic constitution specimens were HE Stained and Observed by light microscope, and classified four lots of morphology (nodular hyperplasia, atypical hyperplasia, prostatic intraepithelial neoplasia and carcinoma). By the SPSS 10.0 statistics software and Chi-square test we find out their inter-correlations.Results (1)Three pathologic factors(kidney deficiency , Dampness and Heat , Blood Stasis ) occupied 85 percents of 100 cases . (2)There is significant difference between age of Syndrome of Qi Stagnation and Blood Stasis and Syndrome of Deficiency of Kindey Yin or Syndrome of Insufficiency of Gastroplenic Qi(p=0.037,0.002). There is also significant correlation between prostatic gland weight and age(Index is 0.26,P=0.021).(3)The P between histology and age is 0.01, age of PIN lot has significant difference with other morphology lots. The age is also significant difference between PIN lot and nodular hyperplasia lot (P=0.03). It makes clear the age and prostate weight of syndromes of air sluggish and Blood Stasis and PIN lot have significant difference Compared with their respective Correspondence syndromes or lots. The percentage of PIN in Syndrome of Qi Stagnation and Blood Stasis is significant higher than that of others syndromes of TCM , P < 0.01 .So there is significant correlation between Syndrome of Qi Stagnation and Blood Stasis and PIN.Conclusion Tt seems that Syndrome of Qi Stagnation and Blood Stasis of BPH has morphologic evidence.更多还原