【作者】 付洪河；

【导师】 舒旭；

【作者基本信息】 黑龙江中医药大学 ， 中西医结合临床， 2004， 硕士

【摘要】 目的：评价止痹痛药酒治疗RA的有效性与安全性。 实验研究：方法：运用弗氏完全佐剂所致大鼠关节炎作为类风湿关节炎的模型，观察止痹痛药酒对模型鼠关节肿胀度和关节组织病理变化的影响。结果：止痹痛药酒能轻模型鼠关节肿胀度，对免疫注射后继发病变具有良好的治疗作用，说明该药具有抗炎免疫作用，病理学观察证实该药能减轻关节滑膜的充血水肿和炎细胞浸润、抑制滑膜细胞增生，减轻关节软骨和软骨下骨组织的破坏程度，抑制模型鼠患肢的致残。临床研究：方法：100例病人随机分入止痹痛药酒研究组52例，和扶他林组48例，分别服用止痹痛药酒(10ml po Bid)和扶他林(50mg poBid)，30天为一个疗程，共治疗3个疗程，所有病人在治疗前和实验结束后测定临床指标：包括晨僵、握力、关节肿胀指数、关节压痛指数、关节功能障碍指数、15m步行时间(秒)、血沉(ESR)、类风湿因子(RF)、C反应蛋白(CRP)。结果：治疗三个月后，上述主要症状和体征，两组均较治疗前有显著改善，(P＜0.05，P＜0.01)但止痹痛药组优于扶他林组，对ESR、CRP的作用，止痹痛药酒组优于扶他林组(P＜0.05)，止痹痛药酒近期控制与显效率为78.8％，总有效率为94.2％；扶他林组近期控制与显效率为52.1％，总有效率为87.5％，止痹痛药酒显效率优于扶他林组，(P＜0.05)更多还原

【Abstract】 Object: To evaluate the effect and safety of Medicated Wine of "zhibitong "Experimental study : The animal model of adjuvant arthritis is established on wistar rat, we treated the animal model with Medicated Wine of Zhibitong ,then learned the therapeutic effect by measuring the animal model joint swelling and performing pathological examinations .Result: The Medicated Wine of Zhibitong can reduce the degree of rat arthriosis swell andhas favorable therapeutic effects to the secondary affection.indicated that the ZBT has anti-inflamma-torry and immune effects. The pathological findings showed that ZBT could alliviate the synovial tissue’s inflammatory congestion, edema, remit the inflammatory cell infiltration and inhibit the proliferation of synovial cells, therefore reduce the degree of destruction of the articular cartilage and subcartilaginous bone tissue. Inhibited the disablement of the woulded limbs. Clinical study: Methods: one-hundred patients were divided into the treatment group (n=52) who were treated exclusively with The Medicated Wine of Zhibitong (10ml po bid ) ; and the control group ( n=48 ) who were treated with votalin ( 50mg po Bid ) .the effect was evaluated after 3-month treatment. The results showed that after 3-month ,the symptoms and sign ,such as morning stiffness ,power of gripping, joint pain ,swelling ,pressing pain ,of patients improved in both groups . But the treatment group had a better effect than the control group ( p < 0.01 or p< 0.05 ) , ESR , CRP in the treatment group decreased more and faster than those in control group ( p< 0.05,p< 0.01 ),short-term control , effective and none effective, radio of the two groups were as follows ,15,26,3 and 6,19,6 ( p< 0.05 ), It is indicated that the treatment group can improve symptoms and signs of patients withRA ,has better and faster effects than control group , and has no obvious side effect.更多还原