【作者】 何秀丽；

【导师】 谢宁；

【作者基本信息】 黑龙江中医药大学 ， 中医基础理论， 2004， 硕士

【摘要】 老年性痴呆是一种进行性神经退行性病变，严重危害老年人的健康。现代医学对老年性痴呆的研究尚没有公认的，可效的药物问世。祖国医学虽然没有“老年性痴呆”这一病名，但对其症状和诊疗经验却有大量的论述。我们基于中医理论和已有的对老年性痴呆的研究成果和诊疗经验，认为老年性痴呆是以肾虚为内在机理，以痰瘀阻窍为致病的重要因素。因此，我们创造性地运用古方地黄饮子进行防治老年性痴呆实验的研究。 本实验以D-半乳糖拟衰老合并基底核注射鹅膏蕈氨酸导致的大鼠老年性痴呆复合模型，并以西药喜得镇为阳性对照，对地黄饮子组从行为学，病理改变，生化酶学改变等方面进行了综合研究，结果表明地黄饮子具有：1．可改善老年性痴呆大鼠行为学功能。2．降低模型大鼠脑组织乙酰胆碱酯酶的含量。3．提高模型大鼠三磷酸腺苷酶的含量。4．能改善老年性痴呆大鼠的脑组织病理改变。证明地黄饮子是一种预防老年性痴呆的有效方药，为治疗老年性痴呆提供了部分实验依据。更多还原

【Abstract】 Alzheimer’s disease is one kind of degenereratly neuropathic diease, it seriously damages the aging health. But there aren’t effective medicines to be sure on treating Alzheimer’s disease generally modern medicine. Compound Chinese medicinal isn’t the name of Alzheimer’s disease, but there are plenty of records in traditional. Chinese medicine such as syndromes and treaded experience. Based on the theory or researched achievements and the experiences in traditional Chinese medicine, we expound two viewpoints:first, kidney’s deficiency is an insternal mechanism of forming senile dementia and second, phlegm is the important factor of causing senile dementia.This experiment take rats of which IBO was injected into the hippocampus as the model animals, and take hydergine group as an opposite group, then we carry out an comprehensive research on the DR group concerning the behavioral science, the pathological change and biochemical change of AchE and ATP estarase. The result proved the effects of DR: 1 .It could improve the behavioral function of the AD rats. 2.It could decrease the brain AchE levels. 3.The activity Na+K+-ATP esterase, Ca2+-ATP esterase were improved. 4.It could improve the pathological change in the AD rats’ brain. This research concludes that the DR is one kind of effective medicine which can prevent the AD.更多还原