四氢巴马汀对雌性大鼠血清中催乳素水平的影响

【作者】 宫照东；

【导师】 尤春来；

【作者基本信息】 辽宁中医学院 ， 药理学， 2003， 硕士

【摘要】 目的：观察四氢巴马汀的左旋体（左旋四氢巴马汀，L-THP）和消旋体（消旋四氢巴马汀，dl-THP）对培高利特（Pergolide Mesytate Salt，Per）及溴隐亭（Bromocriptine，Bro）诱导的雌性大鼠催乳素（Prolactin，PRL）水平低下的影响。方法：通过对雌性大鼠皮下注射（sc）Per或Bro建立雌性大鼠PRL水平低下模型，在此模型基础上，腹腔注射（ip）L-THP和dl-THP，研究L-THP和dl-THP对Per及Bro诱导的雌性大鼠PRL水平低下的影响。结果：皮下注射（sc）Per或Bro可显著而迅速地降低雌性大鼠的血清PRL水平，腹腔注射（ip）L-THP，可对抗用Per或Bro诱导的雌性大鼠血清PRL水平低下的作用；腹腔注射（ip）dl-THP，对Per或Bro诱导的雌性大鼠血清PRL水平低下几乎无影响。结论：L-THP可能是D₂受体拮抗剂。更多还原

【Abstract】 OBJECTIVE: Studying the effects of .L-tetrahydropalmatine (L-THP) and d1- tetrahydropalmatine (dl-THP) to female rats with low serum prolaction(PRL) caused by pergolide (Per) and bromocriPtine (Bro). METHODS:The model of female rats with low serum PRL was made by Subcutaneous Injection of Per and Bro. Then , injecting the L-THP and dl-THP to these models by intraperitone way to study the effects of L-THP and dl-THP on the level of serum PRL. RESULTS: The level of serum PRL of female rats was remarkably and quickly reduced by injecting Per and Bro. And the reduction effects can be antagonized by injecting Injecting L-THP. However, injecting dl-THP has no such effects to the models. CONCLUSION: L-THP may be considered as an antagonist of dopamine D2 receptors.更多还原