复方炙甘草颗粒治疗冠心病室性早搏临床观察

【作者】 吴晏；

【导师】 鲁卫星；

【作者基本信息】 北京中医药大学 ， 中西医结合心血管， 2003， 硕士

【摘要】 随着生活水平提高和生活方式的改变，冠心病的发病率随之提高，而心律失常也是一种常见的疾病。中医药防治冠心病室性早搏也成了研究焦点。 本论文分为文献综述于临床研究两部分。 文献综述分别从中医研究和西药治疗研究两个角度，探讨中医药对冠心病室性早搏病因病机的认识及近十年来在治法和实验研究进展。并对室性早搏的西药治疗作了简要归纳。 临床研究中，采用随机双盲双模拟对照方法，以复方炙甘草颗粒(炙甘草、红参、大枣、生地黄、麦冬、阿胶、火麻仁、桂枝、生姜)为治疗药，以稳心颗粒为对照药治疗冠心病室性早搏(气阴两虚型)病人40例。结果表明，复方炙甘草颗粒有缓解心律失常症状，减少室性早搏次数等疗效，其疗效与稳心颗粒相当，在中医症状改善方面某些优于稳心颗粒(P＜0.05)。进而探讨了室性早搏气阴两虚证的病机特点，以及益气养阴药物治疗心悸的疗效机理，从临床上证实益气养阴法是治疗心悸的有效方法之一。更多还原

【Abstract】 With the development of living level and the alteration of life style, the morbidity of coronary heart disease (CHD) tends to be increasing in China. And cardiac arrhythmia is a usually seen disease. How to prevent and cure CHD and ventricular premature beat (VBP) with Chinese medicine (CM) has become a popular focus.Two parts in the thesis: document reviews and clinical research.Document review: In this part, opinions of ancient CM in the etiology, pathogenesis, differentiation and treatment of VBP are discussed, including the review of therapies and experiment researches of the past 10 years. Moreover, the medical management of VBP are summarized in this part.Clinical research: 40 patients of VBP belonged to deficiency of both qi and blood type were divided into FuFangZhiGanCaoKeLi (FFZGCKL) group and WenXinKeLi group. FFZGCKL group is the treat group and another is the control one. A randomized double-blind-double-imitate-control parallel method is used in this research. Result: Compared with the WenXinKeLi group, the FFZGCKL group haas the same effects in the VBP level and sum decrease, but has significant effects (P<0.05) in symptom recission. It suggests that "nourish qi and blood method" is one of the most effective methods to cure palpilation.更多还原