【作者】 史凤磊；

【导师】 郭伟星；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2002， 硕士

【摘要】 本研究以“脉痹”理论为基础，结合冠心病心绞痛的临床特点，提出“心脉痹”的概念，认为“风、湿、郁、热”是其病因，制定出热痹证型的辩证依据。拟定清热通络、祛风胜湿之法，并以中医理论为基础，参照现代药理研究，严密组方。用此方治疗冠心病心绞痛患者29例，设对照组27例。结果表明：1．冠心病心绞痛患者与健康组相比存在着炎性反应及免疫损伤（P＜0.05），治疗组与对照组相比具有良好的疗效（P＜0.05）；2．治疗组在血流变、TXB₂/6-PGF_1α值、心电图及心功能等方面的疗效均优于对照组（P＜0.05），治疗组与对照组治疗前后相比血脂改变无显著差异（P＜0.05），但治疗组有改善趋势：3．临床症状改善方面，治疗组总有效率79.31％，对照组总有效率51.85％，有显著性差异（P＜0.05）。研究证明：1．“脉痹”理论在指导该病治疗中具有重要应用价值，“风、湿、郁、热”导致“（心脉）不通”与“（心脏）不荣”为其基本病机。2．清热通络、祛风胜湿是治疗该病的重要治法，机理主要是通过抗炎、调节免疫、改善血流变等收效。本研究丰富了中医药治疗冠心病心绞痛的理论内容，为临床治疗提供了新的有效途径。更多还原

【Abstract】 The study is based on the theory of vessel impediment, according to clinical characteristics of coronary heart disease and cardiac angina, suggest the notion of heart vessel impediment, consider the basic pathogeny of it are wind, wet, depression and heat, and then formulate the identify pattens gist. Draw up the way of coping with the disease that is reducing fever and freeing the network vessels, dispersing pathogenic wind and eliminating dampness, and group formular according to modern pharmacology study and TCM theory. With this formular we treat 29 patients with coronary heart disease and angina pectoris accompay with 27 cases as control group. The result shows:1. compared with health group, there are inflammatory reaction and immunologic mjury in the patients with coronary heart disease and angina pectoris (p<0. 05) , the treated group possess favorable curative effect by comparison to control group (p<0. 05) ; The treatment group is more effective than the control group in theseaspects-hemorheology, alpha value of txb2/6 - pgf 1, cardiogram and heart function etc. (P<0. 05) , in the blood fat aspect, there are no significant difference, but the remedy trend is existence in the treatment group.; 3. in the clinical symptom total curative effect aspect, the total effective ratio of treatment group is 79. 31%, the total effective ratio of control group is 51.85%, they have significant difference (P<0. 05) . The study shows: 1. the theory of vessel impediment has important application value in treating the disease, wind, wet, depression and heat that lead to the occlusion of heart vessel and cardiac innutrition is the basic pathogenesis of vessel impediment. 2. the important Therapeutic measure to treat the disease is reducing fever and freeing the network vessels, its mechanism mainly is antiinflammatory, regulating immunity and ameliorating hemorheology produce effects. The research enrich the theory of TCM treating coronary heart disease with cardiac angina, it supply a new efficient path for clinical treatment.更多还原