非平衡涨落理论用于分子马达研究

【作者】 支联合；

【导师】 李玉晓；

【作者基本信息】 郑州大学 ， 粒子物理与核物理， 2002， 硕士

【摘要】 分子马达是细胞内的能量转化器和营养物质的运输器。它的定向运动机制是现在诸多学科研究的前沿和热点。本文首次提出了双头相互作用的分子马达定向运动机制的模型，尝试了物理上研究分子马达定向运动机制的新方法。本文内容包括：首先综述生物学领域分子马达研究的最新进展，内容安排为：肌球蛋白的结构和功能，驱动蛋白的结构和功能，肌球蛋白和驱动蛋白定向运动机制的结构生物学方面的最新进展；其次综述并分析了当前研究分子马达定向运动机制的几种物理模型，内容安排为：分子马达运动的基本观点和建构模型的一般方法，势垒的两态涨落诱导的分子马达运动模型，分子马达定向运动的偶极子模型；最后讨论双头相互作用的分子马达模型，内容安排为：先详细论述模型的构建，再建立Langevin方程和Fokker-Planck方程，接着用差分的方法求解出Fokker-Planck方程的解，然后分析和研究分子马达定向运动的机制。更多还原

【Abstract】 Molecular motor plays an important role in material transporting and energy converting in cell. Several subjects are paying increasingly close attention to its mechanism of unidirectional movement today. Under the guidance of my teacher, a new model on unidirectional motion of molecular motor is put forward, in which the interaction between two heads is taken into account for the first time. The thesis includes three parts: Firstly, previous study and latest advance of molecular motor in biology are outlined, including Myosin’s and Kinesin’s construction and function, the latest advance of molecular motor in constructional biology ;Secondly ,the latest advance of molecular motor in physics is reviewed, including the general view of Brownian motor and two examples of molecular motor, one being related to two kinds of flashing potention energy,the other being related to electronical bipole; And finally, the model on unidirectional motion of molecular motor is in detail come up with ,and especially,the interaction between two heads is taken into account, followed by the construction of Langevin equation and Fokker-Planck equation involved in the model.By using solutions of Fokker-Planck equation, unidirectional motion mechanism of molecular motor is analyzed.更多还原