中国南方汉族哮喘人群IgE高亲和力受体β链基因E237G突变与健康人群的对比研究

【作者】 曾林祥；

【导师】 周世良；

【作者基本信息】 江西医学院 ， 呼吸内科， 2000， 硕士

【摘要】 Objecti\"ef To ana1yze the assoc1at 1on between Fc s RI-- Dgene E237G variant and asthma in the peoD1e of the Haflnat iona1 itv of south china.Methods’ Amp1 1 fi cat iofl refractory mutat ion system PCR(:AR)IS--PCR) was used to determine Fc E RI-- D gene E237Gvariallt 1n 69 unre1ated pat 1 ents wi th asthma and 28 hea1 thycoritro1s frOm the peoD1e of the Han nationa1 f1ty of sotlth{h i na.ResLlltsf E2;37(i was detected in 8 subjects l’rom 69d.thlnat ics (l l. 6%), afld l in 28 hea1t[1y contro1s (3. d796).The TreqLlenc }- of genot ype E237G 1oc i i n asthfl1at i c s’ G1 u/’G l }rgent)t Vpe accotlnt s tor 7. 2o9b, G1 y/’G1y genotype t:1. 3d9b andGl u (j1u 88. ’1ub. There was no significant ditference ifl thet’reqtlence ot coding variaflt E237G 1n asthmat i cs or h1gh IgEl ’nv.e1 group cofnpared wi th norTna1 group.Conclusion: We are unab1e to confirm that the Fc E RI-0 ge12e E237G variant is associated with asthma or IgE1evels in the peop1e of the Han nat1ona1 ity off South China.更多还原

【Abstract】 Objecti\"ef To ana1yze the assoc1at 1on between Fc s RI-- Dgene E237G variant and asthma in the peoD1e of the Haflnat iona1 itv of south china.Methods’ Amp1 1 fi cat iofl refractory mutat ion system PCR(:AR)IS--PCR) was used to determine Fc E RI-- D gene E237Gvariallt 1n 69 unre1ated pat 1 ents wi th asthma and 28 hea1 thycoritro1s frOm the peoD1e of the Han nationa1 f1ty of sotlth{h i na.ResLlltsf E2;37(i was detected in 8 subjects l’rom 69d.thlnat ics (l l. 6%), afld l in 28 hea1t[1y contro1s (3. d796).The TreqLlenc }- of genot ype E237G 1oc i i n asthfl1at i c s’ G1 u/’G l }rgent)t Vpe accotlnt s tor 7. 2o9b, G1 y/’G1y genotype t:1. 3d9b andGl u (j1u 88. ’1ub. There was no significant ditference ifl thet’reqtlence ot coding variaflt E237G 1n asthmat i cs or h1gh IgEl ’nv.e1 group cofnpared wi th norTna1 group.Conclusion: We are unab1e to confirm that the Fc E RI-0 ge12e E237G variant is associated with asthma or IgE1evels in the peop1e of the Han nat1ona1 ity off South China.更多还原