【摘要】 目的 分析数字减影血管造影(DSA)参数联合血清半乳糖凝集素3(GAL3)、P-选择素(CD62P)对缺血性脑卒中的诊断价值。方法 于2022年8月至2024年8月，选取齐齐哈尔市第一医院收治的缺血性脑卒中患者105例作为病例组，依据不同狭窄程度分为轻度组39例、中度组27例、重度组28例、闭塞组11例。以及同期非缺血性脑卒中的颅脑血管疾病患者105例作为对照组，Spearman相关分析DSA参数、GAL3、CD62P与狭窄程度的相关性，ROC曲线分析DSA参数联合血清GAL3、CD62P单一及联合检测对缺血性脑卒中的诊断价值。结果 与对照组相比，病例组TTP、CD62P、MTT、GAL3水平升高(P<0.05)。且MTT、TTP、CD62P、GAL3水平随着狭窄的不断加重而呈现升高趋势(P<0.05)。Spearman相关分析结果显示，MTT、TTP、GAL3、CD62P均与狭窄程度呈正相关(P<0.05)。ROC曲线显示，与血清GAL3、CD62P、TTP、MTT单项诊断相比，联合诊断准确性、敏感度更高(P<0.05)。结论 缺血性脑卒中患者血清GAL3、CD62P及DSA参数升高，可作为诊断缺血性脑卒中的生物学标志物。更多还原

【Abstract】 Objective To analyze the diagnostic value of digital subtraction angiography(DSA) parameters combined with serum galactose lectin 3(GAL3) and P-selectin(CD62P) in ischemic stroke.Methods From August 2022 to August 2024,105 patients with ischemic stroke admitted to the First Hospital of Qiqihar City were selected as the case group, and were divided into mild group(39 cases),moderate group(27 cases),severe group(28 cases),and occlusion group(11 cases) according to different degrees of stenosis.105 patients with cerebrovascular disease and non ischemic stroke during the same period were selected as the control group.Spearman correlation analysis was conducted to investigate the correlation between DSA parameters, GAL3,CD62P,and stenosis degree.ROC curve analysis was used to evaluate the diagnostic value of DSA parameters combined with serum GAL3,CD62P single and combined detection for ischemic stroke.Results Compared with the control group, the levels of TTP,CD62P,MTT,and GAL3 increased in the case group(P<0.05).The levels of MTT,TTP,CD62P,and GAL3 showed an increasing trend with the worsening of stenosis(P<0.05).Spearman correlation analysis showed that MTT,TTP,GAL3,and CD62P were positively correlated with the degree of stenosis(P<0.05).The ROC curve shows that compared with the single diagnosis of serum GAL3,CD62P,TTP,and MTT,the combined diagnosis has higher accuracy and sensitivity(P<0.05).Conclusion Elevated serum GAL3,CD62P,and DSA parameters in patients with ischemic stroke can serve as biological markers for diagnosing ischemic stroke.更多还原