【摘要】 目的 研究桑白皮(Cortex Mori)的化学成分及其抗菌活性。方法 采用薄层层析、柱层析和高效液相色谱等方法对桑白皮中的化学成分进行分离和纯化，并运用核磁共振波谱技术鉴定其结构，最后通过牛津杯法对分离得到的化合物进行抗菌活性研究。结果 从桑白皮中分离得到 13 个化合物，分别鉴定为kuwanon A(1)、kuwanon C(2)、moracin P(3)、moracin O(4)、桑根酮C(5)、morusignin L(6)、physcion-8-O-β-D-glucopyranoside(7)、albanin A(8)、桑辛素(9)、桑辛素M(10)、morunigrol B(11)、kuwanon H(12)和5-dehydroxy-moracin U(13)。结论 化合物7、13为首次从桑白皮中分离得到。化合物2、8、12能够有效抑制枯草芽孢杆菌，化合物5、12对腐生葡萄球菌有一定的抑制效果。更多还原

【Abstract】 Objective To determine the chemical constituents and antimicrobial activity of Cortex Mori (Morus alba L.).Methods Compounds were isolated and purified with thin-layer chromatography (TLC),open column chromatography,and high-performance liquid chromatography (HPLC).Their structures were elucidated through nuclear magnetic resonance (NMR) spectroscopy,and their antimicrobial activities were evaluated with the Oxford-Cup method.Results Thirteen compounds were isolated and identified as kuwanon A (1),kuwanon C (2),moracin P (3),moracin O (4),sanggenon C (5),morusignin L (6),physcion-8-O-β-D-glucopyranoside (7),albanin A (8),morusin (9),morusin M (10),morunigrol B (11),kuwanon H (12),and 5-dehydroxy-moracin U (13).Conclusion Compounds 7 and 13 have been obtained from Cortex Mori for the first time.Compounds 2,8,and 12 exhibit obvious inhibitory effect against Bacillus subtilis,while compounds 5 and 12 display moderate activity against Staphylococcus saprophyticus.更多还原