【摘要】 评估了N-乙酰神经氨酸及其与视黄醇的组合物在皮肤抗衰方面的功效。D-半乳糖诱导的衰老成纤维细胞模型表明，N-乙酰神经氨酸显著降低衰老标志物并促进胶原蛋白合成，表现出剂量依赖性。人体抗衰研究显示，N-乙酰神经氨酸与视黄醇组合在质量比1∶1下显著提升皮肤弹性，显示出协同效果。在三维全层皮肤模型中，该组合物促进胶原蛋白表达，并增加表皮厚度。因此，N-乙酰神经氨酸是一种有效的皮肤抗衰老成分，尤其当与视黄醇联用时，能提供额外的皮肤弹性改善效果。更多还原

【Abstract】 The efficacies of N-acetylneuraminic acid and its combination with retinol in skin anti-aging were evaluated. In a Dgalactose-induced fibroblast aging model, N-acetylneuraminic acid significantly reduced the expression of aging markers and promoted the synthesis of collagen in a dose-dependency manner. In human anti-aging research, a combination of Nacetylneuraminic acid and retinol significantly improved skin elasticity especially at a mass ratio of 1∶1, exhibiting synergistic effects. In a reconstituted three-dimensional full-thickness skin model, the combination promoted collagen expression and increased epidermal thickness. Consequently, N-acetylneuraminic acid is an effective anti-aging skin ingredient, particularly when combined with retinol, which provides additional improvement in skin elasticity.更多还原