【摘要】 肠道微生物组是“人类第二套基因组”,在人体营养吸收与合成、能量转化与代谢、免疫发育与调节等关键生理机能中起着至关重要的作用。腹泻型肠易激综合征(diarrhea-predominant irritable bowel syndrome, IBS-D)是目前公认的与肠道微生态联系最为密切的疾病之一。尽管大多数研究表明肠道微生物组及其代谢物可能通过激活黏膜免疫炎症反应、破坏肠黏膜屏障、增加内脏敏感、改变胃肠道动力、影响脑-肠轴在IBS-D的发生和发展中发挥作用，但仍无法确定微生物组与IBS-D发病机制之间的因果关系。本文总结了微生物代谢组学技术在研究中医药治疗IBS-D作用机制中的应用，探讨当前针对肠道微生物组的中医药研究方法和前景。更多还原

【Abstract】 The gut microbiome is ″the second set of human genome″, playing a crucial role in key physiological functions such as nutrient absorption and synthesis, energy conversion and metabolism, immune development and regulation. Diarrhea-predominant irritable bowel syndrome(IBS-D) is currently recognized as one of the most closely related diseases to the gut microbiota. Although most studies have shown that the gut microbiome and its metabolites may play a role in the occurrence and development of IBS-D by activating mucosal immune inflammatory responses, disrupting the intestinal mucosal barrier, increasing visceral sensitivity, altering gastrointestinal motility, and affecting the brain-gut axis, the causal relationship between the microbiome and the pathogenesis of IBS-D cannot be determined. This article summarized the application of microbial metabolomics technology in the study of the mechanism of traditional Chinese medicine in treating IBS-D, and explored the current research methods and prospects of traditional Chinese medicine for intestinal microbiome.更多还原