【摘要】 目的 探讨血清血小板与淋巴细胞计数比值(PLR)、系统性免疫炎性反应指数(SII)、胱抑素C(Cys C)与大血管闭塞性急性脑梗死患者机械取栓术后血管复流程度的相关性及意义。方法 选取2021年4月至2024年5月南阳市中心医院收治的200例大血管闭塞性急性脑梗死患者，根据取栓术后血管是否完全复流分为完全组、非完全组。比较两组基线资料、术前PLR、SII、Cys C水平，分析PLR、SII、Cys C与取栓术后血管复流程度的相关性及预测血管完全复流的价值。结果 非完全组高血栓负荷患者占比、穿刺至再通时间、PLR、SII、Cys C高于完全组(P<0.05); Spearman相关性分析，PLR、SII、Cys C与血管复流程度呈负相关(P<0.001);偏相关性分析，校正了混杂因素后，PLR、SII、Cys C仍与取栓术后血管复流程度呈显著的相关性(P<0.001); ROC分析显示，单一因子中，Cys C预测血管完全复流的AUC最大，PLR+SII+Cys C的AUC大于Cys C(P<0.05)。结论 PLR、SII、Cys C与大血管闭塞性急性脑梗死机械取栓术后血管复流程度有关，可作为预测血管复流程度的标志物，联合检测三者能进一步提高预测性能，为临床早期预测复流情况和治疗等提供参考。更多还原

【Abstract】 Objective To investigate the correlation and significance of the ratio of serum platelet to lymphocyte count ratio( PLR),systemic inflammatory response index( SII),cystatin C( Cys C) in blood with the degree of vascular recanalization in patients with acute cerebral infarction due to large vessel occlusion after mechanical thrombectomy. Methods Two hundred patients with acute cerebral infarction due to large vessel occlusion were admitted to Nanyang Central Hospital from April 2021 to May 2024 were selected. They were categorized into a complete group and an incomplete group based on whether the blood vessel reopened completely after thrombectomy.The baseline data,preoperative PLR,SII,and Cys C levels were compared between the two groups. The correlation betweenPLR,SII,and Cys C and the degree of blood vessel reopening after thrombectomy,as well as their predictive value for complete blood vessel reopening,were analyzed. Results The proportion of patients with incomplete group high thrombus burden,puncture to recanalization time,PLR,SII,and Cys C were higher in the complete group( P<0. 05); Spearman correlation analysis showed that PLR,SII,and Cys C were negatively correlated with the degree of vascular recanalization( P<0. 001); partial correlation analysis,after adjusting for confounding factors,showed that PLR,SII,and Cys C remained significantly correlated with the degree of vascular recanalization after thrombectomy( P < 0. 001); ROC analysis showed that among single factors,Cys C had the highest AUC for predicting complete vascular recanalization,and the AUC of PLR + SII + Cys C was greater than that of Cys C( P<0. 05). Conclusions PLR,SII,and Cys C are associated with the degree of vascular recanalization after mechanical thrombectomy in patients with acute cerebral infarction due to large vessel occlusion,which are potential markers for predicting the degree of vascular recanalization. The combined detection of the three can further improve predictive performance,providing important reference information for early clinical prediction of reflow conditions and treatment.更多还原