【摘要】 目的 探讨卵巢中肾样腺癌的临床病理特征及诊断要点。方法 对2例卵巢中肾样腺癌进行病理形态学观察及免疫表型分析，并复习相关文献。结果 病例1为右侧卵巢中肾样腺癌，伴软骨样异源性成分；病例2为左侧卵巢中肾样腺癌。两例共同免疫表型：Pax-8、错配修复蛋白（MLH1、MSH2、MSH6、PMS2）均阳性，p53呈野生型表达，CK7弥漫/大部阳性，GATA-3大部/部分阳性，HNF-1β、CD10、ER少数散在或部分阳性，P16斑驳或局灶阳性，calretinin、WT-1、PR均阴性；Ki-67增殖指数约40%。差异表达：病例1 TTF-1阳性、napsin A少数阳性；病例2 TTF-1及napsin A均阴性。结论 卵巢中肾样腺癌是一种罕见的侵袭性女性生殖系统肿瘤，诊断主要依赖病理组织学及免疫组化检测。GATA-3具有一定特异性，错配修复蛋白常为阳性，ER/PR/WT-1/calretinin多阴性；TTF-1和napsin A表达存在异质性。更多还原

【Abstract】 Objective To investigate the clinicopathological characteristics and diagnostic features of ovarian mesonephric-like adenocarcinoma. Methods Pathological morphological observation and immunophenotypic analysis were performed on two cases of ovarian mesonephric-like adenocarcinoma, and relevant literature was reviewed. Results Case 1 was a right-sided ovarian mesonephric-like adenocarcinoma with heterologous cartilaginous components; Case 2 was a left-sided ovarian mesonephric-like adenocarcinoma. The common immunophenotypes of the two cases were: positive for Pax-8 and mismatch repair proteins(MLH1, MSH2, MSH6, PMS2), wild-type p53 expression, diffusely/largely positive for CK7, largely/partially positive for GATA-3, scattered or partially positive for HNF-1β, CD10, and ER, patchy or focally positive for P16, and negative for calretinin, WT-1, and PR. The Ki-67 proliferation index was approximately 40%. Differential expression: Case 1 was positive for TTF-1 and scattered positive for napsin A; Case 2 was negative for both TTF-1 and napsin A. Conclusion Ovarian mesonephric-like adenocarcinoma is a rare and aggressive tumor of the female genital tract. Its diagnosis primarily relies on pathological histology and immunohistochemical detection. GATA-3 exhibits a certain degree of specificity, mismatch repair proteins are often positive, while ER/PR/WT-1/calretinin are mostly negative. The expression of TTF-1 and napsin A shows heterogeneity.更多还原