【摘要】 目的：探讨围手术期肺腺癌在不同表皮生长因子受体(EGFR)基因突变状态下中医证候演变的特点。方法：回顾性分析2019年6月-2023年6月因肺腺癌行肺癌根治术和EGFR基因检测的病例，收集围手术期的中医四诊资料。结果：共纳入106例，EGFR突变型48例，野生型58例。突变型术前1天以气滞血瘀型常见，术后第1天以痰热壅肺型常见，术后第3天和第7天均以气滞血瘀型常见；野生型术前1天和术后第1天均以脾虚痰湿型常见，术后第3天和第7天均以气阴两虚型常见。两组围手术期中医证候的差异有统计学意义(P<0.05)。结论：EGFR基因突变状态与肺腺癌围手术期中医证候具有相关性，突变型以气滞血瘀型为主，野生型以脾虚痰湿型和气阴两虚型为主。更多还原

【Abstract】 Objective: To investigate the evolvement characteristics of epidermal growth factor receptor(EGFR) gene and traditional Chinese medicine(TCM) syndrome differentiation during the perioperative period in lung adenocarcinoma. Methods: From June 2019 to June 2023, the cases of radical operation for lung adenocarcinoma and EGFR gene tests were retrospectively analyzed, meanwhile the data of four examinations in TCM during the perioperative period were collected. Results: A total of 106 patients were included, among whom 48 had mutant genotype and 58 had wild-type geno type. In the group of mutant genotype, the most common syndromes were Qi(气) stagnation blood stasis type before operation, sputum and heat obstruction lung type in the first postoperative day, and Qi stagnation blood stasis type in the third and the seventh postoperative day. In the group of wild-type genotype, the most common syndromes were spleen deficiency and dampness-heat type before operation and in the first postoperative day, and Qi-Yin(阴) deficiency type in the third and the seventh postoperative day. There was a statistically significant in the TCM syndromes during the perioperative period between the two groups(P<0.05). Conclusion: There is a correlation between EGFR gene and TCM syndrome type during the perioperative period in lung adenocarcinoma. The mutant genotype is mainly associated with Qi stagnation blood stasis type, while the wild-type genotype tends to present with spleen deficiency and dampness-heat type and QI-Yin deficiency type.更多还原