【摘要】 大多数肿瘤细胞和健康的神经元均处于G0期的静止状态，一旦在某些条件下异常地重新进入细胞周期，肿瘤细胞的增殖和神经元的变性坏死就可启动。因此，从细胞周期的角度，癌症和中枢神经系统疾病这两种看似不同的疾病类型具有共同的发病机制，这种类型的疾病被命名为细胞周期异常疾病。微小RNA-1976(miR-1976)作为最近新发现的一种微小RNA,与细胞周期的调控密切相关。本文主要综述miR-1976在癌症及中枢神经系统疾病中的研究进展，以期为未来miR-1976在细胞周期异常疾病中的临床应用提供参考。更多还原

【Abstract】 Most tumor cells and healthy neurons are at rest during G0 phase.Once the cell cycle is abnormally re-entered under certain conditions, the proliferation of tumor cells and the degenerative necrosis of neurons can be initiated.From the perspective of the cell cycle, cancer and central nervous system diseases, two seemingly different disease types, have a common pathogenesis.This type of diseases is named aberrant cell cycle diseases.As a newly discovered microRNA(miR),miR-1976 is closely related to the regulation of the cell cycle.This review summarizes the progress in the research on miR-1976 in cancer and central nervous system diseases, aiming to provide a reference for the clinical application of miR-1976 in aberrant cell cycle diseases in the future.更多还原