【摘要】 细胞自噬信号通路主要包括PI3K/Akt/mTOR通路、p38 MAPK通路、TAK1/JNK通路和AMPK通路，参与调节树突状细胞（DC）的成熟和免疫功能。肿瘤坏死因子α诱导蛋白8样分子2(TIPE2)是维持免疫稳态的重要调控蛋白，TIPE2可通过调控细胞自噬信号通路进而维持DC的免疫功能稳定。本文综述细胞自噬信号通路在DC功能中的作用，并对细胞自噬信号通路的潜在调控分子TIPE2进行阐述，以期为DC免疫功能障碍相关疾病研究提供理论依据。更多还原

【Abstract】 Autophagy signal pathways mainly include PI3K/Akt/mTOR pathway, p38 MAPK pathway, TAK1/JNK pathway and AMPK pathway, which are involved in regulating the maturation and immune function of dendritic cell(DC). Tumor necrosis factor-α-inducible protein-8-like molecule 2(TIPE2) is an important regulatory protein to maintain immune homeostasis. TIPE2 can maintain the stability of immune function of DC by regulating cell autophagy signal pathway. This article reviews the role of cell autophagy signal pathway in DC function and the potential regulatory molecule TIPE2 of cell autophagy signal pathway, in order to provide a theoretical basis for the research on related diseases of immune dysfunction in DC.更多还原