【摘要】 瘢痕疙瘩是一种常见的良性皮肤纤维增生性疾病，其特征是成纤维细胞过度增生和细胞外基质的过度积累。越来越多的研究发现，瘢痕疙瘩与特应性皮炎、骨质疏松、高血压、子宫肌瘤等其他系统性疾病存在密切联系，且瘢痕疙瘩患者伴发这类疾病的风险明显高于一般人群。这种共病现象对患者的身心健康造成了极大的困扰，也是临床诊疗过程中十分棘手的问题。本文通过总结现有与瘢痕疙瘩相关的共病研究，分析这些疾病与瘢痕疙瘩的流行病学特点，以及可能的共病机制和病理生理学特征，为临床防治瘢痕疙瘩共病提供新的视角与思路，从而改善患者预后和提高生活质量。更多还原

【Abstract】 Keloids are a common benign fibroproliferative disorder characterized by fibroblast hyperproliferation and excessive extracellular matrix deposition.Emerging evidence demonstrates significant associations between keloids and systemic diseases including atopic dermatitis, osteoporosis, hypertension and uterine fibroids.Keloid patients exhibit markedly higher risks of these comorbidities compared to the general population.This comorbidity phenomenon has caused significant impairment to patients′ physical and mental health.It is also a major clinical challenge in the process of clinical diagnosis and treatment.This article summarizes the existing studies on keloid-related comorbidities, analyzes the epidemiological characteristics of these diseases and keloids, as well as the possible co-pathogenesis and pathophysiological characteristics, and provides a new perspective and ideas for clinical prevention and treatment of keloid comorbidities, ultimately improving patient prognosis and quality of life.更多还原